Maggio F, Pasciuto T, Paffi A, Apollonio F, Parazzini M, Ravazzani P, d'Inzeo G
ICEmB @ Department of Electronic Engineering, Univeristy of Rome "La Sapienza", 00184, Italy.
Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:2057-60. doi: 10.1109/IEMBS.2010.5626487.
Deep Brain Stimulation (DBS) is a clinically suitable technique for the treatment of the Parkinson's disease. Recently, also other neurological disorders such as Tourette syndrome, obsessive-compulsive disorder, epilepsy are being to be treated with DBS. However, the debate on its therapeutic mechanisms of action is still open. In order to a better understanding of such mechanisms, in this work the attention is focused on the DBS micro-stimulation. Indeed, a micro electrodes registration and stimulation is a fundamental step, during the surgical phase, to optimize the technique in terms of DBS lead positioning and DBS signal parameters. In this paper a dosimetric analysis with micro electrodes has been carried out, showing a more focused distribution of the electrical potential induced in the neuroanatomical tissues and changes of the excited/inhibited regions, respect to a macro electrodes stimulation.
深部脑刺激（DBS）是一种临床上适用于治疗帕金森病的技术。最近，其他一些神经系统疾病，如妥瑞氏症、强迫症、癫痫，也开始采用DBS进行治疗。然而，关于其治疗作用机制的争论仍在继续。为了更好地理解这些机制，在这项工作中，注意力集中在DBS微刺激上。事实上，微电极记录和刺激是手术阶段的一个基本步骤，以便在DBS电极定位和DBS信号参数方面优化该技术。本文进行了微电极剂量分析，结果表明，与宏观电极刺激相比，神经解剖组织中感应的电势分布更集中，兴奋/抑制区域也发生了变化。
