Department of Information Engineering, Electronics and Telecommunication, Sapienza University of Rome, 00184 Rome, Italy ; Italian Inter-University Center for the Study of Electromagnetic Fields and Biological Systems (ICEmB), 16145 Genova, Italy.
Biomed Res Int. 2013;2013:262739. doi: 10.1155/2013/262739. Epub 2013 Oct 7.
Deep brain stimulation is a clinical technique for the treatment of parkinson's disease based on the electric stimulation, through an implanted electrode, of specific basal ganglia in the brain. To identify the correct target of stimulation and to choose the optimal parameters for the stimulating signal, intraoperative microelectrodes are generally used. However, when they are replaced with the chronic macroelectrode, the effect of the stimulation is often very different. Here, we used numerical simulations to predict the stimulation of neuronal fibers induced by microelectrodes and macroelectrodes placed in different positions with respect to each other. Results indicate that comparable stimulations can be obtained if the chronic macroelectrode is correctly positioned with the same electric center of the intraoperative microelectrode. Otherwise, some groups of fibers may experience a completely different electric stimulation.
脑深部电刺激是一种基于电刺激的帕金森病治疗临床技术，通过植入大脑中的特定基底神经节的电极来实现。为了确定正确的刺激靶点并选择最佳的刺激信号参数，通常会使用术中微电极。然而，当将它们替换为慢性的粗电极时，刺激效果往往会有很大的不同。在这里，我们使用数值模拟来预测微电极和粗电极放置在彼此不同位置时对神经元纤维的刺激。结果表明，如果慢性粗电极以与术中微电极相同的电中心正确定位，就可以获得可比较的刺激效果。否则，一些纤维组可能会经历完全不同的电刺激。
