Sassi Marco, Zekaj Edvin, Grotta Alessandra, Pollini Alberto, Pellanda Armando, Borroni Massimo, Pacchetti Claudio, Menghetti Claudia, Porta Mauro, Servello Domenico
Functional Neurosurgical Unit, IRCCS Galeazzi, Milan, Italy; Department of Statistics, University of Milano-Bicocca, Milan, Italy; Department of Neurology, IRCCS C. Mondino Institute of Neurology Foundation, University of Pavia, Pavia, Italy.
Neuromodulation. 2013 Sep-Oct;16(5):401-6; discussion 406. doi: 10.1111/j.1525-1403.2012.00483.x. Epub 2012 Jul 10.
Evaluation of safety and efficacy of dexmedetomidine in deep brain stimulation (DBS) surgery.
A cohort of 23 patients, candidates for DBS for Parkinson's disease, Tourette syndrome, or obsessive-compulsive disorder, was randomized in two groups: dexmedetomidine group and control group. Standard anesthesiologic parameters were recorded and analyzed, together with the need for other medications. A ten-degree scale (visual analog scale) assessing patient discomfort during DBS also was recorded at the end of surgery.
The results demonstrated good stability of intraoperative monitoring: no respiratory depression and good overall cooperation with the neurologist, while no side-effects were recorded.
Our conclusion is that dexmedetomidine should be considered as a valuable option for sedation in poorly collaborating patients undergoing DBS surgery.
评估右美托咪定在脑深部电刺激（DBS）手术中的安全性和有效性。
将23例因帕金森病、图雷特综合征或强迫症而适合接受DBS治疗的患者随机分为两组：右美托咪定组和对照组。记录并分析标准麻醉参数以及其他药物的使用需求。手术结束时还记录了一个评估患者在DBS期间不适程度的10级量表（视觉模拟量表）。
结果显示术中监测稳定性良好：无呼吸抑制，与神经科医生总体配合良好，且未记录到副作用。
我们的结论是，对于接受DBS手术且配合不佳的患者，右美托咪定应被视为一种有价值的镇静选择。
