右美托咪定（普瑞博思）用于脑深部电刺激手术的安全性：我们对23例随机患者的经验。
Safety in the use of dexmedetomidine (precedex) for deep brain stimulation surgery: our experience in 23 randomized patients.
作者信息
Sassi Marco, Zekaj Edvin, Grotta Alessandra, Pollini Alberto, Pellanda Armando, Borroni Massimo, Pacchetti Claudio, Menghetti Claudia, Porta Mauro, Servello Domenico
机构信息
Functional Neurosurgical Unit, IRCCS Galeazzi, Milan, Italy; Department of Statistics, University of Milano-Bicocca, Milan, Italy; Department of Neurology, IRCCS C. Mondino Institute of Neurology Foundation, University of Pavia, Pavia, Italy.
出版信息
Neuromodulation. 2013 Sep-Oct;16(5):401-6; discussion 406. doi: 10.1111/j.1525-1403.2012.00483.x. Epub 2012 Jul 10.
OBJECTIVE
Evaluation of safety and efficacy of dexmedetomidine in deep brain stimulation (DBS) surgery.
MATERIALS AND METHODS
A cohort of 23 patients, candidates for DBS for Parkinson's disease, Tourette syndrome, or obsessive-compulsive disorder, was randomized in two groups: dexmedetomidine group and control group. Standard anesthesiologic parameters were recorded and analyzed, together with the need for other medications. A ten-degree scale (visual analog scale) assessing patient discomfort during DBS also was recorded at the end of surgery.
RESULTS
The results demonstrated good stability of intraoperative monitoring: no respiratory depression and good overall cooperation with the neurologist, while no side-effects were recorded.
CONCLUSIONS
Our conclusion is that dexmedetomidine should be considered as a valuable option for sedation in poorly collaborating patients undergoing DBS surgery.
目的
评估右美托咪定在脑深部电刺激（DBS）手术中的安全性和有效性。
材料与方法
将23例因帕金森病、图雷特综合征或强迫症而适合接受DBS治疗的患者随机分为两组：右美托咪定组和对照组。记录并分析标准麻醉参数以及其他药物的使用需求。手术结束时还记录了一个评估患者在DBS期间不适程度的10级量表（视觉模拟量表）。
结果
结果显示术中监测稳定性良好：无呼吸抑制，与神经科医生总体配合良好，且未记录到副作用。
结论
我们的结论是，对于接受DBS手术且配合不佳的患者，右美托咪定应被视为一种有价值的镇静选择。
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