用于生物医学应用的 CMOS 低电流测量系统。
CMOS low current measurement system for biomedical applications.
机构信息
Department of Electrical Engineering, Yale University, New Haven, CT 06520, USA.
出版信息
IEEE Trans Biomed Circuits Syst. 2012 Apr;6(2):111-9. doi: 10.1109/TBCAS.2011.2182512.
We present a micro-chip implementation of a low current measurement system for biomedical applications using capacitive feedback that exhibits 190 fA of RMS noise in a 1 kHz bandwidth. The sampling rate is selectable up to 100 kHz. When measuring the amplifier noise with a 10 GΩ resistor and a 47 pF capacitor at the input, typical of cell membrane capacitance in DNA and patch clamp experiments, the measured RMS noise was 2.44 pA on a 50 pA signal in a 10 kHz bandwidth. Two channels were implemented on 630 × 440 μm² using a 0.5-μm 3-metal 2-poly CMOS process. Each channel consumes 1.5 mW of power from a 3.3 V supply. We measured the characteristics of an artificial lipid bilayer similar to the ones used in DNA sequencing experiments via nanopores.
我们提出了一种使用容性反馈的低电流测量系统的微芯片实现，该系统在 1 kHz 带宽下表现出 190 fA 的 RMS 噪声。采样率可选高达 100 kHz。当在输入处使用 10 GΩ 电阻和 47 pF 电容测量放大器噪声时，典型的细胞膜电容在 DNA 和膜片钳实验中，在 10 kHz 带宽下，50 pA 的信号上测量的 RMS 噪声为 2.44 pA。两个通道在 630 × 440 μm² 的面积上使用 0.5-μm 3 金属 2 多晶硅 CMOS 工艺实现。每个通道从 3.3 V 电源消耗 1.5 mW 的功率。我们通过纳米孔测量了类似于用于 DNA 测序实验的人工脂质双层的特性。
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