Watanabe Hiroki, Yamazaki Nozomu, Kobayashi Yo, Miyashita Tomoyuki, Hashizume Makoto, Fujie Masakatsu G
Graduate School of Science and Engineering, Waseda University, Japan.
Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:3222-8. doi: 10.1109/IEMBS.2010.5627200.
Radiofrequency ablation (RFA) for liver cancer has increasingly been used over the past few years because RFA is minimally invasive treatment for patients. However, precise control of the formation of coagulation zones is difficult for operators due to inadequate imaging modalities. With this in mind, we have proposed a model-based robotic ablation system using numerical simulation to analyze temperature distributions in the organ to overcome this deficiency. The objective of our work is to develop a temperature-dependent thermophysical organ model to construct a precise numerical simulator for RFA. However, no standard methods exist for obtaining the thermophysical properties of biological tissues, as detailed evaluations of the accuracy of properties obtained from various experiments have not been completed. The purpose of this study was thus to measure and model the temperature dependence of thermal conductivity in hog liver from three representative methods, and to compare these results using our developed numerical simulator to reveal differences in temperature distributions stemming from differences in thermal conductivities.
在过去几年中，肝癌的射频消融（RFA）应用越来越广泛，因为RFA对患者而言是一种微创治疗方法。然而，由于成像方式不足，操作人员难以精确控制凝固区的形成。考虑到这一点，我们提出了一种基于模型的机器人消融系统，利用数值模拟来分析器官中的温度分布，以克服这一缺陷。我们工作的目标是开发一个与温度相关的热物理器官模型，构建一个用于RFA的精确数值模拟器。然而，目前尚无获取生物组织热物理特性的标准方法，因为尚未完成对各种实验所得特性准确性的详细评估。因此，本研究的目的是通过三种代表性方法测量并模拟猪肝热导率的温度依赖性，并使用我们开发的数值模拟器比较这些结果，以揭示热导率差异导致的温度分布差异。
