Yamazaki Nozomu, Watanabe Hiroki, Lu Xiaowei, Isobe Yosuke, Kobayashi Yo, Miyashita Tomoyuki, Fujie Masakatsu G
Annu Int Conf IEEE Eng Med Biol Soc. 2013;2013:386-91. doi: 10.1109/EMBC.2013.6609518.
Radio frequency ablation (RFA) for lung cancer has increasingly been used over the past few years because it is a minimally invasive treatment. As a feature of RFA for lung cancer, lung contains air during operation. Air is low thermal and electrical conductivity. Therefore, RFA for this cancer has the advantage that only the cancer is coagulated, and it is difficult for operators to control the precise formation of coagulation lesion. In order to overcome this limitation, we previously proposed a model-based robotic ablation system using finite element method. Creating an accurate thermo physical model and constructing thermal control method were a challenging problem because the thermal properties of the organ are complex. In this study, we measured electromagnetic wave frequency dependence of lung's electrical conductivity that was based on lung's internal air volumes dependence with in vitro experiment. In addition, we validated the electromagnetic wave frequency dependence of lung's electrical conductivity using temperature distribution simulator. From the results of this study, it is confirmed that the electromagnetic wave frequency dependence of lung's electrical conductivity effects on heat generation of RFA.
在过去几年中,肺癌的射频消融(RFA)因其微创性而越来越多地被使用。作为肺癌RFA的一个特点,手术过程中肺内含有空气。空气的热导率和电导率较低。因此,这种癌症的RFA具有仅使癌症发生凝固的优点,但操作者难以控制凝固性病变的精确形成。为了克服这一局限性,我们之前提出了一种基于有限元方法的基于模型的机器人消融系统。创建精确的热物理模型和构建热控制方法是一个具有挑战性的问题,因为器官的热特性很复杂。在本研究中,我们通过体外实验测量了基于肺内空气体积依赖性的肺电导率的电磁波频率依赖性。此外,我们使用温度分布模拟器验证了肺电导率的电磁波频率依赖性。从本研究结果可以确认,肺电导率的电磁波频率依赖性对RFA的发热有影响。