Toennies Jenna L, Ciuti Gastone, Smith Byron F, Menciassi Arianna, Valdastri Pietro, Webster Robert J
Vanderbilt University, Nashville, TN 37235, USA.
Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:1946-9. doi: 10.1109/IEMBS.2010.5627793.
Toward increasing the diagnostic ability of wireless capsule endoscopy, we propose a method to wirelessly insufflate the Gastrointestinal Tract. By increasing the viewable surface area, it appears likely that capsule-based insufflation may reduce the number of false negative diagnoses made by endoscopic capsules. Our approach to wireless insufflation is to utilize controlled phase transition of a small volume of fluid stored onboard the capsule to a large volume of gas that is then emitted into the intestine. We begin by describing experiments designed to evaluate the amount of gas a capsule must produce to have a beneficial impact on visualization in the colon. We then describe experiments evaluating how much gas can be generated from a given volume of fluid, using Hydrogen Peroxide as our working fluid. We also evaluate thermal effects of the Hydrogen Peroxide reaction. The cumulative result of these experiments is an illustration of the feasibility of carrying a sufficient volume of fluid onboard a wireless capsule to generate a beneficial enhancement in visualization of the interior of the Gastrointestinal Tract, and specifically the colon.
为了提高无线胶囊内镜的诊断能力，我们提出一种对胃肠道进行无线充气的方法。通过增加可视表面积，基于胶囊的充气似乎有可能减少内镜胶囊做出的假阴性诊断数量。我们的无线充气方法是利用储存在胶囊内的少量流体向大量气体的可控相变，然后将气体排放到肠道中。我们首先描述旨在评估胶囊必须产生多少气体才能对结肠可视化产生有益影响的实验。然后我们描述使用过氧化氢作为工作流体，评估从给定体积的流体中可以产生多少气体的实验。我们还评估过氧化氢反应的热效应。这些实验的累积结果表明，在无线胶囊内携带足够体积的流体以对胃肠道内部，特别是结肠的可视化产生有益增强是可行的。
