Pasricha Trisha, Smith Byron F, Mitchell Victoria R, Fang Brian, Brooks Erik R, Gerding Jason S, Washington Mary Kay, Valdastri Pietro, Obstein Keith L
School of Medicine, Vanderbilt University, Nashville, Tennessee, United States.
Department of Mechanical Engineering, Vanderbilt University, Nashville, Tennessee, United States.
Endoscopy. 2014 Jul;46(7):614-8. doi: 10.1055/s-0034-1365497. Epub 2014 May 20.
Capsule endoscopy is an attractive alternative to colorectal cancer screening by conventional colonoscopy, but is currently limited by compromised mucosal visibility because of the lack of safe, controlled colonic insufflation. We have therefore developed a novel system of untethered, wireless-controlled carbon dioxide (CO2) insufflation for use in colonic capsule endoscopy, which this study aims to assess in vivo.
This observational, nonsurvival, in vivo study used five Yorkshire-Landrace cross swine. A novel insufflation capsule was placed in the porcine colons, and we recorded volume of insufflation, time, force, visualization, and a pathologic assessment of the colon.
The mean (standard deviation [SD]) diameter of insufflation was 32.1 (3.9) mm. The volume of CO2 produced successfully allowed complete endoscopic visualization of the mucosa and safe proximal passage of the endoscope. Pathologic examination demonstrated no evidence of trauma caused by the capsule.
These results demonstrate the feasibility of a novel method of controlled colonic insufflation via an untethered capsule in vivo. This technological innovation addresses a critical need in colon capsule endoscopy.
胶囊内镜是传统结肠镜用于结直肠癌筛查的一种有吸引力的替代方法，但目前由于缺乏安全、可控的结肠充气，黏膜可视性受损而受到限制。因此，我们开发了一种用于结肠胶囊内镜检查的新型无束缚、无线控制二氧化碳（CO₂）充气系统，本研究旨在对其进行体内评估。
本观察性、非存活体内研究使用了5头约克夏-长白杂交猪。将一个新型充气胶囊置于猪结肠内，记录充气量、时间、压力、可视情况以及对结肠的病理评估。
充气的平均（标准差[SD]）直径为32.1（3.9）mm。成功产生的CO₂量使内镜能够完全观察到黏膜，并使内镜安全通过近端。病理检查未发现胶囊造成创伤的证据。
这些结果证明了通过无束缚胶囊在体内进行可控结肠充气新方法的可行性。这一技术创新满足了结肠胶囊内镜检查的一项关键需求。
