Department of Neurology, Royal Victoria Hospital, Belfast, UK.
J Neurol Neurosurg Psychiatry. 2011 Jan;82(1):110-6. doi: 10.1136/jnnp.2010.212407. Epub 2010 Nov 19.
Abnormal eye movements are increasingly recognised in patients with amyotrophic lateral sclerosis (ALS) and, when they occur, may provide insights into the pattern and pathogenesis of the disease process. In patients with disorders that mimic ALS, abnormal eye movements may point to the correct diagnosis. In both of these circumstances, systematic examination of eye movements and interpretation of the findings with reference to modern concepts of their neural substrate will aid diagnosis and suggest pathogenesis. Here, key points with illustrative case histories and eye movement records are highlighted.
眼球运动异常在肌萎缩侧索硬化症（ALS）患者中越来越常见，出现这些异常时，可能有助于深入了解疾病过程的模式和发病机制。在类似 ALS 的疾病患者中，眼球运动异常可能指向正确的诊断。在这两种情况下，系统地检查眼球运动，并参考其神经基础的现代概念来解释检查结果，将有助于诊断并提示发病机制。本文重点介绍了具有说明性病史和眼动记录的关键点。
