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Complete genome sequence of the probiotic Lactobacillus casei strain BL23.益生菌干酪乳杆菌 BL23 全基因组序列。
J Bacteriol. 2010 May;192(10):2647-8. doi: 10.1128/JB.00076-10. Epub 2010 Mar 26.
2
Complete genome sequence of the probiotic Lactobacillus rhamnosus ATCC 53103.益生菌鼠李糖乳杆菌ATCC 53103的全基因组序列
J Bacteriol. 2009 Dec;191(24):7630-1. doi: 10.1128/JB.01287-09. Epub 2009 Oct 9.
3
Two distinct alpha-L-fucosidases from Bifidobacterium bifidum are essential for the utilization of fucosylated milk oligosaccharides and glycoconjugates.来自两歧双歧杆菌的两种不同的α-L-岩藻糖苷酶对于利用岩藻糖基化乳寡糖和糖缀合物至关重要。
Glycobiology. 2009 Sep;19(9):1010-7. doi: 10.1093/glycob/cwp082. Epub 2009 Jun 11.
4
The genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiome.婴儿双歧杆菌亚种的基因组序列揭示了其在婴儿微生物群中对利用乳汁的适应性。
Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18964-9. doi: 10.1073/pnas.0809584105. Epub 2008 Nov 24.
5
Mucin degradation by Bifidobacterium strains isolated from the human intestinal microbiota.从人体肠道微生物群中分离出的双歧杆菌菌株对黏蛋白的降解作用。
Appl Environ Microbiol. 2008 Mar;74(6):1936-40. doi: 10.1128/AEM.02509-07. Epub 2008 Jan 25.
6
Glycoprofiling of bifidobacterial consumption of human milk oligosaccharides demonstrates strain specific, preferential consumption of small chain glycans secreted in early human lactation.双歧杆菌对人乳寡糖的糖谱分析表明，其对人类早期哺乳期分泌的小链聚糖具有菌株特异性的优先消耗作用。
J Agric Food Chem. 2007 Oct 31;55(22):8914-9. doi: 10.1021/jf0710480. Epub 2007 Oct 5.
7
In vitro fermentation of breast milk oligosaccharides by Bifidobacterium infantis and Lactobacillus gasseri.婴儿双歧杆菌和加氏乳杆菌对母乳中低聚糖的体外发酵
Appl Environ Microbiol. 2006 Jun;72(6):4497-9. doi: 10.1128/AEM.02515-05.
8
Molecular cloning and characterization of Bifidobacterium bifidum 1,2-alpha-L-fucosidase (AfcA), a novel inverting glycosidase (glycoside hydrolase family 95).两歧双歧杆菌1,2-α-L-岩藻糖苷酶（AfcA）的分子克隆与特性分析，一种新型的转化糖苷酶（糖苷水解酶家族95）
J Bacteriol. 2004 Aug;186(15):4885-93. doi: 10.1128/JB.186.15.4885-4893.2004.
9
Fucose: biosynthesis and biological function in mammals.岩藻糖：哺乳动物中的生物合成与生物学功能
Glycobiology. 2003 Jul;13(7):41R-53R. doi: 10.1093/glycob/cwg054. Epub 2003 Mar 19.

新型益生菌干酪乳杆菌来源的α-L-岩藻糖苷酶对天然岩藻糖基化低聚糖的利用

Utilization of natural fucosylated oligosaccharides by three novel alpha-L-fucosidases from a probiotic Lactobacillus casei strain.

机构信息

Laboratorio de Bacterias Lácticas y Probióticos, Instituto de Agroquímica y Tecnología de los Alimentos, Consejo Superior de Investigaciones Científicas, Paterna, Valencia, Spain.

出版信息

Appl Environ Microbiol. 2011 Jan;77(2):703-5. doi: 10.1128/AEM.01906-10. Epub 2010 Nov 19.

DOI:10.1128/AEM.01906-10
PMID:21097595
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3020537/
Abstract

Three putative α-L-fucosidases encoded in the Lactobacillus casei BL23 genome were cloned and purified. The proteins displayed different abilities to hydrolyze natural fucosyloligosaccharides like 2'-fucosyllactose, H antigen disaccharide, H antigen type II trisaccharide, and 3'-, 4'-, and 6'-fucosyl-GlcNAc. This indicated a possible role in the utilization of oligosaccharides present in human milk and intestinal mucosa.

摘要

从干酪乳杆菌 BL23 基因组中克隆并纯化了三种假定的α-L-岩藻糖苷酶。这些蛋白对天然岩藻糖基低聚糖（如 2'-岩藻糖基乳糖、H 抗原二糖、H 抗原 II 型三糖以及 3'、4'、6'-岩藻糖基-GlcNAc）的水解能力不同。这表明它们可能在利用人乳和肠道黏膜中存在的寡糖方面发挥作用。