Department of Neurobiology, Karolinska Institutet, Care Sciences and Society, Huddinge, Sweden.
Rheumatology (Oxford). 2011 Mar;50(3):578-85. doi: 10.1093/rheumatology/keq356. Epub 2010 Nov 21.
The aims of this study were to investigate hand function in PM and DM patients and compare this with reference values in healthy individuals and also to investigate if hand function correlated with activity performance and health-related quality of life.
An observational cross-sectional study was performed in 18 women and 13 men with PM or DM with established disease. Grip force and hand mobility were assessed by Grippit and Escola Paulista de Medicina-Range of Motion scale. Activity performance was measured with myositis activities profile and health-related quality of life by short form-36 (SF-36).
Women and men with PM and DM with mean disease duration of 6.8 (5.5) years had a significantly lower grip force than gender- and age-matched healthy individuals (women 71% and men 60%). They also had significantly lower mean values in all dimensions of the health-related quality of life instrument SF-36 compared with the Swedish population. In patients with PM and DM, the grip force correlated significantly with the ability to perform domestic activities. In women with PM and DM, the grip force correlated significantly with the health-related quality of life dimensions vitality and mental health. There were no significant differences between patients with PM and DM regarding grip force, hand mobility, activity performance or health-related quality of life.
Patients with PM or DM have reduced grip force that could influence activity performance and health-related quality of life.
本研究旨在调查皮肌炎（PM）和多发性肌炎（DM）患者的手部功能，并将其与健康人群的参考值进行比较，同时还研究手部功能是否与活动能力和健康相关的生活质量相关。
对 18 名女性和 13 名男性 PM 或 DM 患者进行了一项观察性横断面研究，这些患者的疾病均已确诊。通过 Grippit 和 Escola Paulista de Medicina-Range of Motion 量表评估握力和手部活动度。使用肌炎活动度评分和简短形式 36 健康调查量表（SF-36）来评估活动能力和健康相关的生活质量。
患有 PM 和 DM 的女性和男性患者的平均疾病病程为 6.8（5.5）年，其握力明显低于性别和年龄匹配的健康人群（女性为 71%，男性为 60%）。与瑞典人群相比，他们在 SF-36 健康相关生活质量量表的所有维度上的平均得分也明显较低。在 PM 和 DM 患者中，握力与进行家庭活动的能力显著相关。在患有 PM 和 DM 的女性中，握力与健康相关生活质量的活力和心理健康维度显著相关。PM 和 DM 患者之间在握力、手部活动度、活动能力或健康相关的生活质量方面无显著差异。
PM 或 DM 患者的握力降低，这可能会影响活动能力和健康相关的生活质量。
