呋咱并呋喃酮途径早期步骤的多样性。
Diversity of the early step of the futalosine pathway.
机构信息
Biotechnology Research Center, Toyama Prefectural University, Toyama, Japan.
出版信息
Antimicrob Agents Chemother. 2011 Feb;55(2):913-6. doi: 10.1128/AAC.01362-10. Epub 2010 Nov 22.
Abstract
We recently demonstrated that the futalosine pathway was operating in some bacteria for the biosynthesis of menaquinone and that futalosine was converted into dehypoxanthinyl futalosine (DHFL) by an MqnB of Thermus thermophilus. In this study, we found that aminodeoxyfutalosine, which has adenine instead of hypoxanthine in futalosine, was directly converted into DHFL by an MqnB of Helicobacter pylori. Therefore, this step is potentially an attractive target for the development of specific anti-H. pylori drugs.
摘要
我们最近证明，在某些细菌中， futalosine 途径用于 menaquinone 的生物合成，并且 futalosine 被 Thermus thermophilus 的 MqnB 转化为去羟嘌呤基 futalosine (DHFL)。在这项研究中，我们发现，氨基脱氧 futalosine 是 futalosine 中的腺嘌呤取代了次黄嘌呤，它可以被幽门螺杆菌的 MqnB 直接转化为 DHFL。因此，这一步骤可能是开发特异性抗幽门螺杆菌药物的有吸引力的靶点。
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本文引用的文献
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Enzymatic properties of futalosine hydrolase, an enzyme essential to a newly identified menaquinone biosynthetic pathway.呋喃洛辛水解酶的酶学性质，这是一条新发现的甲基萘醌生物合成途径所必需的一种酶。
Biosci Biotechnol Biochem. 2009 May;73(5):1137-41. doi: 10.1271/bbb.80906. Epub 2009 May 7.
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