Department of Periodontology, Tokyo Dental College, Chiba, Japan.
Dent Mater J. 2010 Nov;29(6):721-30. doi: 10.4012/dmj.2010-033. Epub 2010 Nov 19.
The aim of this study was to investigate the effect of β tricalcium phosphate (β-TCP) particle size on recombinant human platelet-derived growth factor-BB (rhPDGF-BB)-induced regeneration of periodontal tissue in dog. The control group (rhPDGF-BB alone) was characterized by incomplete, newly formed bone. The large-particle β-TCP (L-TCP(O))/rhPDGF-BB group showed a statistically significant increase in both new bone and cementum formation compared to the small-particle β-TCP (S-TCP(G))/rhPDGF-BB group. These findings suggest that L-TCP(O)-particle promotes rhPDGF-BB-induced formation of bone and cementum.
本研究旨在探讨β-磷酸三钙（β-TCP）颗粒大小对犬牙周组织中重组人血小板衍生生长因子-BB（rhPDGF-BB）诱导再生的影响。单独使用 rhPDGF-BB 的对照组表现为新骨形成不完全。与小颗粒β-磷酸三钙（S-TCP(G))/rhPDGF-BB 组相比，大颗粒β-磷酸三钙（L-TCP(O))/rhPDGF-BB 组的新骨和牙骨质形成均有显著增加。这些结果表明，L-TCP(O)颗粒促进了 rhPDGF-BB 诱导的骨和牙骨质形成。
