Rokn Amir Reza, Khodadoostan Mohammad Amin, Reza Rasouli Ghahroudi Amir Ali, Motahhary Puria, Kharrazi Fard Mohammad Javad, Bruyn Hugo De, Afzalifar Rose, Soolar Ehsan, Soolari Ahmad
Associate Professor, Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
Open Dent J. 2011;5:96-104. doi: 10.2174/1874210601105010096. Epub 2011 Jul 7.
Although autogenous bone grafts are considered the gold standard for bone regeneration, they have certain limitations, including patient morbidity at the harvest site. Synthetic bone substitutes have been developed to overcome some of these limitations. The present study aimed to compare the osteogenic properties of Straumann Bone Ceramic (SBC), which is a biphasic calcium phosphate, with Bio-Oss, an inorganic bovine bone material, in an animal model.
Thirteen rabbits were included in this study. In each rabbit, four 6.5-mm-diameter identical defects were prepared on the calvarium. One site was filled with Bio-Oss, the second site was treated with small-particle SBC, the third site was treated with large-particle SBC, and the fourth site was left as an untreated control. After 4 and 8 weeks, the animals were sacrificed, and histologic and histomorphometric examinations were performed. The data were analyzed using Friedman and multiple-comparison Mann-Whitney U tests.
There were no statistically significant differences in the amount of bone fill between the four groups. L-SBC showed more inflammation and foreign-body reactions than the other bone substitutes.
No statistically significant differences were found between groups. Further studies on this issue seem necessary.
尽管自体骨移植被认为是骨再生的金标准，但它们存在一定局限性，包括取骨部位的患者发病率。已经开发出合成骨替代物来克服其中一些局限性。本研究旨在在动物模型中比较双相磷酸钙的Straumann骨陶瓷（SBC）与无机牛骨材料Bio-Oss的成骨特性。
本研究纳入了13只兔子。在每只兔子的颅骨上制备四个直径6.5毫米的相同缺损。一个部位填充Bio-Oss，第二个部位用小颗粒SBC处理，第三个部位用大颗粒SBC处理，第四个部位留作未处理的对照。4周和8周后，处死动物并进行组织学和组织形态计量学检查。使用Friedman检验和多重比较Mann-Whitney U检验分析数据。
四组之间的骨填充量没有统计学上的显著差异。大颗粒SBC比其他骨替代物表现出更多的炎症和异物反应。
各组之间未发现统计学上的显著差异。对此问题进行进一步研究似乎很有必要。
