Thoma Daniel S, Jung Ronald E, Hänseler Patrick, Hämmerle Christoph H F, Cochran David L, Weber Franz E
Clinic of Fixed and Removable Prosthodontics and Dental Material Science, University of Zurich, Zurich, Switzerland.
Int J Periodontics Restorative Dent. 2012 Apr;32(2):195-202.
The aim of this study was to test whether recombinant human platelet-derived growth factor BB (rhPDGF-BB) enhances bone regeneration in combination with Β-tricalcium phosphate (Β-TCP) granules or deproteinized bovine bone mineral (DBBM) compared to empty defects and Β-TCP granules alone. Four titanium cylinders were placed on the external cortical plates of seven rabbits' calvaria and randomly allocated to one of four groups: (1) empty, (2) Β-TCP, (3) Β-TCP + rhPDGF-BB, and (4) DBBM + rhPDGF-BB. The mean area of bone regeneration was 13.9% ± 8.4% (empty), 24.0% ± 14.8% (Β-TCP), 37.1% ± 8.9% (Β-TCP + rhPDGF-BB), and 64.4% ± 5.4% (DBBM + rhPDGF-BB), with the greatest bone regeneration noted for DBBM + rhPDGF-BB (P < .01). The fraction of bone substitute material varied between 48.3% ± 9.3% (DBBM + rhPDGF-BB), 53.1% ± 10.6% (Β-TCP + rhPDGF-BB), and 58.0% ± 14.8% (Β-TCP). rhPDGF-BB combined with DBBM showed the greatest potential to enhance bone regeneration.
本研究的目的是测试与单纯的空白缺损和β-磷酸三钙（β-TCP）颗粒相比，重组人血小板衍生生长因子BB（rhPDGF-BB）与β-磷酸三钙颗粒或脱蛋白牛骨矿物质（DBBM）联合使用时是否能增强骨再生。在7只兔子颅骨的外侧皮质板上放置4个钛圆柱体，并随机分配到4组中的一组：（1）空白组，（2）β-TCP组，（3）β-TCP + rhPDGF-BB组，和（4）DBBM + rhPDGF-BB组。骨再生的平均面积分别为13.9%±8.4%（空白组）、24.0%±14.8%（β-TCP组）、37.1%±8.9%（β-TCP + rhPDGF-BB组）和64.4%±5.4%（DBBM + rhPDGF-BB组），其中DBBM + rhPDGF-BB组的骨再生最为显著（P <.01）。骨替代材料的比例在48.3%±9.3%（DBBM + rhPDGF-BB组）、53.1%±10.6%（β-TCP + rhPDGF-BB组）和58.0%±14.8%（β-TCP组）之间变化。rhPDGF-BB与DBBM联合使用显示出增强骨再生的最大潜力。
