Spiller Kara L, Vunjak-Novakovic Gordana
Department of Biomedical Engineering, Columbia University, 622 West 168th Street Vanderbilt Clinic 12-234, New York, NY, 10032, USA.
Drug Deliv Transl Res. 2015 Apr;5(2):101-15. doi: 10.1007/s13346-013-0135-1.
Strategies that utilize controlled release of drugs and proteins for tissue engineering have enormous potential to regenerate damaged organs and tissues. The multiple advantages of controlled release strategies merit overcoming the significant challenges to translation, including high costs and long, difficult regulatory pathways. This review highlights the potential of controlled release of proteins for tissue engineering and regenerative medicine. We specifically discuss treatment modalities that have reached preclinical and clinical trials, with emphasis on controlled release systems for bone tissue engineering, the most advanced application with several products already in clinic. Possible strategies to address translational and regulatory concerns are also discussed.
利用药物和蛋白质的控释用于组织工程的策略在再生受损器官和组织方面具有巨大潜力。控释策略的多重优势值得克服转化过程中的重大挑战，包括高成本以及漫长而艰难的监管途径。本综述强调了蛋白质控释在组织工程和再生医学中的潜力。我们特别讨论了已进入临床前和临床试验阶段的治疗方式，重点是骨组织工程的控释系统，这是最先进的应用，已有几种产品进入临床。还讨论了解决转化和监管问题的可能策略。
Drug Deliv Transl Res. 2015-4
J Control Release. 2015-12-10
Expert Opin Drug Deliv. 2011-6-16
Adv Drug Deliv Rev. 2015-9-28
J Control Release. 2012-3-8
Adv Drug Deliv Rev. 2007-5-30
Adv Drug Deliv Rev. 2010-1-25
Pediatr Res. 2008-5
J Pharm Sci. 2009-2
Adv Healthc Mater. 2025-1
Micromachines (Basel). 2024-4-15
Plast Aesthet Res. 2021
ACS Appl Bio Mater. 2022-7-18
Adv Drug Deliv Rev. 2021-11
Front Chem. 2021-7-9
Int J Mol Sci. 2021-1-18
J Biomed Mater Res B Appl Biomater. 2012-8-22
Adv Drug Deliv Rev. 2012-4-2
J Tissue Eng Regen Med. 2012-3-7
Adv Drug Deliv Rev. 2012-2-4
Tissue Eng Part B Rev. 2012-2-8
Zotero 插件