Yamanaka Takashi, Bannai Hiroshi, Nemoto Manabu, Tsujimura Koji, Kondo Takashi, Matsumura Tomio
Epizootic Research Center, Equine Research Institute, Japan Racing Association, 1400–4 Shiba, Shimotsuke, Tochigi 329–0412, Japan.
J Vet Med Sci. 2011 Apr;73(4):483-5. doi: 10.1292/jvms.10-0408. Epub 2010 Nov 19.
In 2010, the World Organisation for Animal Health recommended the inclusion of a Florida sublineage clade2 strain of equine influenza virus (H3N8), which is represented by A/equine/Richmond/1/07 (Richmond07), in equine influenza vaccines. Here, we evaluate the antigenic differences between Japanese vaccine strains and Richmond07 by performing hemagglutination inhibition (HI) assays. Ferret antiserum raised to A/equine/La Plata/93 (La Plata93), which is a Japanese vaccine strain, reacted with Richmond07 at a similar titer to La Plata93. Moreover, two hundred racehorses exhibited similar geometric mean HI antibody titers against La Plata93 and Richmond07 (73.1 and 80.8, respectively). Therefore, we can expect the antibody induced by the current Japanese vaccines to provide some protection against Richmond07-like viruses.
2010年，世界动物卫生组织建议在马流感疫苗中纳入一种佛罗里达亚谱系2型马流感病毒（H3N8）毒株，其代表株为A/equine/Richmond/1/07（Richmond07）。在此，我们通过进行血凝抑制（HI）试验评估日本疫苗株与Richmond07之间的抗原差异。用日本疫苗株A/equine/La Plata/93（La Plata93）免疫雪貂产生的抗血清与Richmond07反应的效价与La Plata93相似。此外，200匹赛马对La Plata93和Richmond07表现出相似的几何平均HI抗体效价（分别为73.1和80.8）。因此，我们可以预期当前日本疫苗诱导产生的抗体能为抵抗Richmond07样病毒提供一定保护。
