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通过在马身上进行攻毒试验评估马流感病毒株的抗原差异。

Assessment of antigenic difference of equine influenza virus strains by challenge study in horses.

作者信息

Yamanaka Takashi, Nemoto Manabu, Bannai Hiroshi, Tsujimura Koji, Kondo Takashi, Matsumura Tomio, Gildea Sarah, Cullinane Ann

机构信息

Equine Research Institute, Japan Racing Association, Shimotsuke, Tochigi, Japan.

Virology Unit, Irish Equine Centre, Johnstown, Naas, Co. Kildare, Ireland.

出版信息

Influenza Other Respir Viruses. 2016 Nov;10(6):536-539. doi: 10.1111/irv.12418. Epub 2016 Aug 9.

DOI:10.1111/irv.12418
PMID:27465864
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5059955/
Abstract

We previously reported that horse antiserum against the Japanese equine influenza vaccine virus, A/equine/La Plata/1993 (LP93) exhibited reduced cross-neutralization against some Florida sublineage Clade (Fc) 2 viruses, for example, A/equine/Carlow/2011 (CL11). As a result, Japanese vaccine manufacturers will replace LP93 with A/equine/Yokohama/aq13/2010 (Y10, Fc2). To assess the benefit of updating the vaccine, five horses vaccinated with inactivated Y10 vaccine and five vaccinated with inactivated LP93 were challenged by exposure to a nebulized aerosol of CL11. The durations of pyrexia (≥38.5°C) and other adverse clinical symptoms experienced by the Y10 group were significantly shorter than those of the LP93 group.

摘要

我们之前报道过，针对日本马流感疫苗病毒A/equine/La Plata/1993（LP93）的马抗血清对某些佛罗里达亚分支进化枝（Fc）2病毒，如A/equine/Carlow/2011（CL11）的交叉中和作用有所降低。因此，日本疫苗制造商将用A/equine/Yokohama/aq13/2010（Y10，Fc2）取代LP93。为评估更新疫苗的益处，给5匹接种了灭活Y10疫苗的马和5匹接种了灭活LP93的马雾化吸入CL11气雾剂进行攻毒。Y10组发热（≥38.5°C）及其他不良临床症状的持续时间明显短于LP93组。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b851/5059955/7203c97d7d77/IRV-10-536-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b851/5059955/7203c97d7d77/IRV-10-536-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b851/5059955/7203c97d7d77/IRV-10-536-g001.jpg

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