Ochi H, Douglass H O, Sandberg A A
Cancer Genet Cytogenet. 1986 Aug;22(4):295-307. doi: 10.1016/0165-4608(86)90022-1.
We have analyzed five primary gastric cancers with a G-banding technique. All tumors had clonal chromosome abnormalities; a total of 67 numerical and 83 structural karyotypic anomalies were identified as clonal. The most prominent and recurring numerical abnormality was a missing Y chromosome (three of four tumors in the male patients). No recurrent structural abnormalities were found. However, the breakpoints at bands 1p22, 3p21, and 19p13 were frequently involved. These chromosome abnormalities and their role in oncogenesis are discussed.
我们运用G显带技术分析了5例原发性胃癌。所有肿瘤均存在克隆性染色体异常；共鉴定出67个染色体数目异常和83个染色体结构核型异常为克隆性异常。最显著且反复出现的染色体数目异常是Y染色体缺失（男性患者的4例肿瘤中有3例）。未发现反复出现的结构异常。然而，1p22、3p21和19p13带的断点频繁受累。本文讨论了这些染色体异常及其在肿瘤发生中的作用。
