Department of Global Health, Kenya Medical Research Institute, PO Box 1578, Kisumu, Kenya.
Br J Cancer. 2010 Nov 23;103(11):1736-41. doi: 10.1038/sj.bjc.6605947.
Endemic Burkitt's lymphoma (eBL) has been associated with Epstein-Barr virus (EBV) and holoendemic Plasmodium falciparum malaria. But recent evidence suggests that other risk factors are involved.
We hypothesised that selenoprotein glutathione peroxidase (GPx), a surrogate of nutritional status, is an important biomarker for eBL risk. We measured plasma GPx, anthropometric markers of malnutrition, EBV viral loads and malaria parasitaemia in children aged 1-9 years (n=258) from two locations in Nyanza Province, Kenya, with higher-than-expected and lower-than-expected incidence of eBL. The study participants were malaria asymptomatic children from the community.
Children from eBL high-incidence areas had significantly lower GPx levels, high EBV viral load and more evidence of chronic malnutrition than children from eBL low-incidence areas (all P<0.001). Additionally, GPx levels were significantly lower in children with the highest EBV viral load and for those with P. falciparum infections (P=0.035 and P=0.004, respectively).
These results suggest that selenium deficiency may be a risk factor for eBL.
地方性伯基特淋巴瘤（eBL）与 Epstein-Barr 病毒（EBV）和全地方性恶性疟原虫疟疾有关。但最近的证据表明，还存在其他风险因素。
我们假设硒蛋白谷胱甘肽过氧化物酶（GPx），一种营养状况的替代物，是 eBL 风险的重要生物标志物。我们在肯尼亚 Nyanza 省的两个地点测量了年龄在 1-9 岁的儿童（n=258）的血浆 GPx、营养不良的人体测量标志物、EBV 病毒载量和疟原虫寄生虫血症。研究参与者是社区中无症状的疟疾儿童。
来自 eBL 高发地区的儿童的 GPx 水平明显较低，EBV 病毒载量较高，且有更多慢性营养不良的证据，而来自 eBL 低发地区的儿童则没有（均 P<0.001）。此外，EBV 病毒载量最高的儿童和感染恶性疟原虫的儿童的 GPx 水平明显较低（P=0.035 和 P=0.004）。
这些结果表明，硒缺乏可能是 eBL 的一个风险因素。
Zotero 插件