Ellis Toby, Eze Elvis, Raimi-Abraham Bahijja Tolulope
King's College London, School of Cancer and Pharmaceutical Sciences, Comprehensive Cancer Centre, Guy's Campus, Great Maze Pond, London, SE1 9RT, UK.
Malaria no More UK, The Foundry, 17 Oval Way, Vauxhall, London, SE11 5RR, UK.
Infect Agent Cancer. 2021 May 13;16(1):33. doi: 10.1186/s13027-021-00370-7.
Cancer and malaria both have high incidence rates and are leading causes of mortality worldwide, especially in low and middle-income countries with reduced access to the quality healthcare. The objective of this critical review was to summarize key associations and new perspectives between the two diseases as is reported in existing literature.
A critical review of research articles published between 1st January 2000 - 1st July 2020 which yielded 1753 articles. These articles were screened based on a precise inclusion criteria. Eighty-nine eligible articles were identified and further evaluated.
Many articles reported anti-cancer activities of anti-malarial medicines, including Artemisinin and its derivatives. Other articles investigated the use of chemotherapy in areas burdened by malaria, treatment complications that malaria may cause for cancer patients as well as ways to circumvent cancer related drug resistance. Potential novel targets for cancer treatment, were identified namely oncofoetal chondroitin sulphate and haem, as well as the use of circumsporozoite proteins. A number of articles also discussed Burkitt lymphoma or febrile neutropenia.
Overall, excluding for Burkitt lymphoma, the relationship between cancer and malaria requires further extensive research in order to define association. There great potential promising new novel anti-cancer therapies using anti-malarial drugs. Created using BioRender.
癌症和疟疾发病率都很高，是全球主要死因，尤其是在难以获得优质医疗保健服务的低收入和中等收入国家。本综述的目的是总结现有文献中报道的这两种疾病之间的关键关联和新观点。
对2000年1月1日至2020年7月1日发表的研究文章进行综述，共检索到1753篇文章。根据精确的纳入标准对这些文章进行筛选。确定了89篇符合条件的文章并进一步评估。
许多文章报道了抗疟药物（包括青蒿素及其衍生物）的抗癌活性。其他文章研究了在疟疾高发地区使用化疗的情况、疟疾可能给癌症患者带来的治疗并发症以及规避癌症相关耐药性的方法。确定了潜在的癌症治疗新靶点，即癌胚硫酸软骨素和血红素，以及环孢子蛋白的应用。一些文章还讨论了伯基特淋巴瘤或发热性中性粒细胞减少症。
总体而言，除伯基特淋巴瘤外，癌症与疟疾之间的关系需要进一步广泛研究以明确关联。使用抗疟药物有很大潜力开发出有前景的新型抗癌疗法。使用BioRender制作。
