Department of Neurobiology and Behavior, Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, California, United States of America.
PLoS One. 2010 Nov 17;5(11):e14015. doi: 10.1371/journal.pone.0014015.
Dietary supplements have been extensively studied for their beneficial effects on cognition and AD neuropathology. The current study examines the effect of a medical food cocktail consisting of the dietary supplements curcumin, piperine, epigallocatechin gallate, α-lipoic acid, N-acetylcysteine, B vitamins, vitamin C, and folate on cognitive functioning and the AD hallmark features and amyloid-beta (Aβ) in the Tg2576 mouse model of the disease.
The study found that administering the medical food cocktail for 6 months improved cortical- and hippocampal- dependent learning in the transgenic mice, rendering their performance indistinguishable from non-transgenic controls. Coinciding with this improvement in learning and memory, we found that treatment resulted in decreased soluble Aβ, including Aβ oligomers, previously found to be linked to cognitive functioning.
In conclusion, the current study demonstrates that combination diet consisting of natural dietary supplements improves cognitive functioning while decreasing AD neuropathology and may thus represent a safe, natural treatment for AD.
膳食补充剂在认知功能和 AD 神经病理学方面的有益作用已得到广泛研究。本研究探讨了由膳食补充剂姜黄素、胡椒碱、表没食子儿茶素没食子酸酯、α-硫辛酸、N-乙酰半胱氨酸、B 族维生素、维生素 C 和叶酸组成的医疗食品鸡尾酒对疾病 Tg2576 小鼠模型认知功能以及 AD 标志性特征和淀粉样蛋白-β（Aβ）的影响。
研究发现，医疗食品鸡尾酒治疗 6 个月可改善转基因小鼠的皮质和海马依赖性学习，使它们的表现与非转基因对照无法区分。与学习和记忆的改善相一致，我们发现治疗导致可溶性 Aβ减少，包括先前与认知功能相关的 Aβ 寡聚物。
总之，本研究表明，由天然膳食补充剂组成的组合饮食可改善认知功能，同时减少 AD 神经病理学，因此可能是 AD 的一种安全、自然的治疗方法。
Zotero 插件
