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Influence of Gold Nanoshell on Hyperthermia of Super Paramagnetic Iron Oxide Nanoparticles (SPIONs).

作者信息

Mohammad Faruq, Balaji Gopalan, Weber Andrew, Uppu Rao M, Kumar Challa S S R

机构信息

Center for Advanced Microstructures & Devices, Louisiana State University, 6980 Jefferson Highway, Baton Rouge, LA 70806. USA.

出版信息

J Phys Chem C Nanomater Interfaces. 2010 Jan 1;114(45):19194-19201. doi: 10.1021/jp105807r.


DOI:10.1021/jp105807r
PMID:21103390
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2987684/
Abstract

Gold nanoshell around super paramagnetic iron oxide nanoparticles (SPIONs) was synthesized and small angle X-ray scattering (SAXS) analysis suggests a gold coating of approximately 0.4 to 0.5 nm thickness. On application of low frequency oscillating magnetic fields (44 - 430 Hz), a four- to five-fold increase in the amount of heat released with gold-coated SPIONs (6.3 nm size) in comparison with SPIONs (5.4 nm size) was observed. Details of the influence of frequencies of oscillating magnetic field, concentration and solvent on heat generation are presented. We also show that, in the absence of oscillating magnetic field, both SPIONs and SPIONs@Au are not particularly cytotoxic to mammalian cells (MCF-7 breast carcinoma cells and H9c2 cardiomyoblasts) in culture, as indicated by the reduction of 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium by viable cells in a phenazine methosulfate-assisted reaction.

摘要

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本文引用的文献

[1]
Superparamagnetic iron oxide nanoparticle 'theranostics' for multimodality tumor imaging, gene delivery, targeted drug and prodrug delivery.

Expert Rev Clin Pharmacol. 2010-1

[2]
Magnetically induced hyperthermia: size-dependent heating power of γ-Fe(2)O(3) nanoparticles.

J Phys Condens Matter. 2008-5-21

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Int J Nanomedicine. 2010-4-7

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J Colloid Interface Sci. 2010-1-18

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Biomaterials. 2010-2-7

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Proc Natl Acad Sci U S A. 2010-2-8

[7]
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[8]
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Biosens Bioelectron. 2009-9-6

[9]
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Nanotechnology. 2009-7-29

[10]
Synthesis of Complexable Fluorescent Superparamagnetic Iron Oxide Nanoparticles (FL SPIONs) and Cell Labeling for Clinical Application.

Adv Mater. 2008-7-2

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