Department of Pharmacology & Therapeutics, Trinity Centre for Health Sciences, St. James's Hospital, Dublin 8, Ireland.
Eur J Clin Pharmacol. 2011 Mar;67(3):301-8. doi: 10.1007/s00228-010-0942-y. Epub 2010 Nov 23.
We examined the prescribing of antiosteoporotic medications pre- and post hospital admission in patients with fragility fractures as well as factors associated with prescribing of these treatments following admission.
We identified all patients aged ≥ 55 years at a large teaching hospital between 2005 and 2008 with a fracture using the Hospital In-Patient Enquiry (HIPE) system. These data were linked to prescribing data from the Health Service Executive Primary Care Reimbursement Services (HSE-PCRS) scheme before and after discharge (821 patients). Logistic regression analysis was used to examine the likelihood of prescription of antiosteoporotic medication pre- and post discharge in relation to year of discharge, age, gender, and type of fracture.
Prescribing of antiosteoporotic treatment before fracture increased from 2.6% [95% confidence interval (CI) 2.23-2.93%] in 2005 to 10.6% (95% CI 9.32-11.86) by 2008, whereas post fracture prescribing increased from 11% (95% CI 9.64-12.36) to 47% (95% CI 43.6-50.3). In patients discharged from hospital in 2007, postfracture prescribing was 31.8% (95% CI 28.66-35.02) at 12 months, increasing to 50.3% (95% CI 46.6-53.9) at 24 months. The highest rate of prescribing was in the 65- to 69-year age group [odds ratio (OR) 8.51, 95% CI 1.75-41.35]. Patients discharged in 2008 were eight times more likely to be treated than patients discharged in 2005 (OR 8.01, 95% CI 4.55-14.09).
The percentage of patients on antiosteoporotic treatment post fracture increased significantly from 2005 to 2008. This may be largely due to the introduction of the Osteoporosis Clinic to the hospital in 2005.
我们研究了脆性骨折患者住院前后抗骨质疏松药物的开具情况,以及与住院后这些治疗方案开具相关的因素。
我们通过医院住院查询系统(HIPE),确定了 2005 年至 2008 年期间一家大型教学医院所有年龄≥55 岁的骨折患者。这些数据与出院前后(821 例患者)卫生服务管理局初级保健报销服务(HSE-PCRS)方案的处方数据相关联。我们采用逻辑回归分析,研究了与出院年份、年龄、性别和骨折类型相关的出院前后开具抗骨质疏松药物的可能性。
骨折前抗骨质疏松治疗的开具率从 2005 年的 2.6%(95%可信区间[CI]2.23%-2.93%)增加到 2008 年的 10.6%(95% CI 9.32%-11.86%),而骨折后开具率从 11%(95% CI 9.64%-12.36%)增加到 47%(95% CI 43.6%-50.3%)。2007 年出院的患者,骨折后开具率在 12 个月时为 31.8%(95% CI 28.66%-35.02%),24 个月时增至 50.3%(95% CI 46.6%-53.9%)。开具率最高的是 65-69 岁年龄组[优势比(OR)8.51,95% CI 1.75-41.35]。与 2005 年出院的患者相比,2008 年出院的患者接受治疗的可能性增加了 8 倍(OR 8.01,95% CI 4.55-14.09)。
从 2005 年到 2008 年,骨折后接受抗骨质疏松治疗的患者比例显著增加。这可能主要归因于 2005 年医院开设了骨质疏松症诊所。