Wagner H, Dorsch W, Bayer T, Breu W, Willer F
Institute of Pharmaceutical Biology, Ludwig-Maximilians University, München, FRG.
Prostaglandins Leukot Essent Fatty Acids. 1990 Jan;39(1):59-62. doi: 10.1016/0952-3278(90)90173-i.
Nine thiosulfinates (TS) and four "Cepaenes" (CS) isolated from onions and/or synthetized by us showed dose dependent (0.25 to 100 microM) marked inhibitory effects on both cyclooxygenase (CA, tested on sheep seminal vesicle microsomes) and 5-lipoxygenase activity (LO, tested on porcine leukocytes). The following rank order of activity was observed: saturated aliphatic TS less than aromatic TS approximately alpha, beta-unsaturated TS less than CS. CS inhibited both CA and LO by more than 75% at 10 and 1 microM concentrations respectively. Most likely, these in vitro effects are responsible for antiinflammatory and antiasthmatic properties of onion extracts observed in vivo, at least in part.
从洋葱中分离出来和/或由我们合成的9种硫代亚磺酸盐（TS）和4种“洋葱烯”（CS），对环氧化酶（在绵羊精囊微粒体上进行测试）和5-脂氧合酶活性（在猪白细胞上进行测试）均呈现出剂量依赖性（0.25至100微摩尔）的显著抑制作用。观察到以下活性顺序：饱和脂肪族TS＜芳香族TS≈α,β-不饱和TS＜CS。CS在浓度为10微摩尔和1微摩尔时分别对环氧化酶和5-脂氧合酶的抑制率超过75%。这些体外效应很可能至少部分地解释了在体内观察到的洋葱提取物的抗炎和平喘特性。
