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洋葱的抗哮喘作用。链（烯）基硫代亚磺酸链（烯）基酯在体外可抑制组胺释放、白三烯和血栓素的生物合成，并在体内对抗血小板活化因子和过敏原诱导的支气管阻塞。

Anti-asthmatic effects of onions. Alk(en)ylsulfinothioic acid alk(en)yl-esters inhibit histamine release, leukotriene and thromboxane biosynthesis in vitro and counteract PAF and allergen-induced bronchial obstruction in vivo.

作者信息

Dorsch W, Wagner H, Bayer T, Fessler B, Hein G, Ring J, Scheftner P, Sieber W, Strasser T, Weiss E

机构信息

Pediatric Department Poliklinik, Ludwig-Maximilians-University, Munich, Federal Republic of Germany.

出版信息

Biochem Pharmacol. 1988 Dec 1;37(23):4479-86. doi: 10.1016/0006-2952(88)90663-6.

DOI:10.1016/0006-2952(88)90663-6
PMID:2462422
Abstract

Five alk(en)ylsulfinothioic acid alk(en)yl-esters isolated from onions and four synthetic thiosulfinates inhibited 5-lipoxygenase of porcine leucocytes, histamine release and leukotriene B4 and C4 biosynthesis of human polymorphonuclear leucocytes, thromboxane B2 biosynthesis by human platelets and allergen- and PAF-induced bronchial obstruction of guinea-pigs. The anti-asthmatic and anti-inflammatory effects of onions depend in part on the thiosulfinate moiety: (Formula: see text).

摘要

从洋葱中分离出的五种链烯基硫代亚磺酸链烯基酯和四种合成硫代亚磺酸盐抑制了猪白细胞的5-脂氧合酶、组胺释放以及人多形核白细胞中白三烯B4和C4的生物合成、人血小板中血栓素B2的生物合成以及变应原和血小板活化因子诱导的豚鼠支气管阻塞。洋葱的抗哮喘和抗炎作用部分取决于硫代亚磺酸盐部分：（分子式：见原文）

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