Sendl A, Elbl G, Steinke B, Redl K, Breu W, Wagner H
Institute of Pharmaceutical Biology, University of Munich, Federal Republic of Germany.
Planta Med. 1992 Feb;58(1):1-7. doi: 10.1055/s-2006-961378.
Extracts of wild garlic (Allium ursinum) and garlic (A. sativum) with defined chemical compositions were investigated for their in vitro inhibitory potential on 5-lipoxygenase (LO), cyclooxygenase (CO), thrombocyte aggregation (TA), and angiotensin I-converting enzyme (ACE). The inhibition rates as IC50 values of both extracts for 5-LO, CO, and TA showed a good correlation with the %-content of the major S-containing compounds (thiosulfinates and ajoenes) of the various extracts. In the 5-LO and CO test the garlic extracts are slightly superior to the wild garlic extracts whereas, in the TA test, no differences could be found. In the ACE test the water extract of the leaves of wild garlic containing glutamyl-peptides showed the highest inhibitory activity followed by that of the garlic leaf and the bulbs of both drugs. The comparative studies underline the usefulness of wild garlic as a substitute of garlic.
对具有明确化学成分的野蒜（熊葱）和大蒜提取物进行了体外抑制5-脂氧合酶（5-LO）、环氧化酶（CO）、血小板聚集（TA）和血管紧张素I转换酶（ACE）潜力的研究。两种提取物对5-LO、CO和TA的抑制率以IC50值表示，与各提取物中主要含硫化合物（硫代亚磺酸盐和阿霍烯）的百分比含量具有良好的相关性。在5-LO和CO试验中，大蒜提取物略优于野蒜提取物，而在TA试验中未发现差异。在ACE试验中，含有谷氨酰肽的野蒜叶水提取物显示出最高的抑制活性，其次是大蒜叶和两种药物的鳞茎提取物。比较研究强调了野蒜作为大蒜替代品的实用性。
