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对联合国儿童基金会/阿拉伯埃及共和国/世界卫生组织在贝赫伊拉省的血吸虫病控制项目的评估。

Evaluation of UNICEF/Arab Republic of Egypt/WHO schistosomiasis Control Project in Beheira Governorate.

作者信息

Spencer H C, Ruiz-Tibén E, Mansour N S, Cline B L

机构信息

Centers for Disease Control, Atlanta, Georgia.

出版信息

Am J Trop Med Hyg. 1990 May;42(5):441-8. doi: 10.4269/ajtmh.1990.42.441.

Abstract

We evaluated the UNICEF/Government of Egypt/WHO Schistosomiasis Control project in 2 districts of Beheira Governorate of the Nile Delta during 3 weeks in February 1988. The project, begun in 1983, was focused on reducing prevalence, intensity, and morbidity due to schistosomiasis by providing diagnosis and treatment with praziquantel to schoolchildren. Schools were visited twice. Following the completion of the school surveys, the program was extended into the community. Chemotherapy was delivered by mobile and static teams. The evaluation indicated that, with respect to accuracy of diagnosis, record-keeping, and coverage of targeted populations, project tasks were performed exceedingly well by highly motivated, well-supervised mobile teams. Static teams in rural health centers were less successful in providing diagnosis and chemotherapy to village populations. We resurveyed 6 randomly selected schools to assess the impact of chemotherapy. Overall, the prevalence of Schistosoma mansoni infection was reduced from 60.3% to 24.8% between the first and second surveys (approximately 1 year apart) and was still lower (41.1%) than initial levels up to 3 years after the last treatment with praziquantel. The percentages of those with greater than or equal to 34 S. mansoni eggs/slide using the Kato-Katz technique showed a marked and prolonged decrease (17.1% to 0.3% to 2.2%). The prevalence of S. haematobium infection dropped from 37.6% to 5.5% and was still 9.9% at the time of the evaluation. The percentages of those with greater than or equal to 50 S. haematobium eggs/10 ml urine dropped less dramatically (17% to 4.4% to 11.9%). Mobile teams conducting vigorous chemotherapy programs targeted at schoolchildren can have long-lasting benefits in terms of prevalence and intensity.

摘要

1988年2月,我们在尼罗河三角洲贝赫伊拉省的2个区对联合国儿童基金会/埃及政府/世界卫生组织血吸虫病控制项目进行了为期3周的评估。该项目始于1983年,重点是通过为学童提供吡喹酮诊断和治疗,降低血吸虫病的流行率、感染强度和发病率。对学校进行了两次走访。学校调查完成后,该项目扩展到社区。化疗由流动和固定团队提供。评估表明,在诊断准确性、记录保存和目标人群覆盖方面,积极性高、监管良好的流动团队出色地完成了项目任务。农村卫生中心的固定团队在为村民提供诊断和化疗方面不太成功。我们对6所随机选择的学校进行了重新调查,以评估化疗的效果。总体而言,曼氏血吸虫感染率在第一次和第二次调查之间(相隔约1年)从60.3%降至24.8%,在最后一次使用吡喹酮治疗后的3年内仍低于初始水平(41.1%)。使用加藤厚涂片法检测,每片曼氏血吸虫卵数≥34个的比例显著且持续下降(从17.1%降至0.3%再降至2.2%)。埃及血吸虫感染率从37.6%降至5.5%,评估时仍为9.9%。每10毫升尿液中埃及血吸虫卵数≥50个的比例下降幅度较小(从17%降至4.4%再降至11.9%)。针对学童开展积极化疗项目的流动团队在流行率和感染强度方面可带来长期益处。

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