Segest E, Mygind O, Bay H
Office of the Commissioner of Health, Copenhagen, Denmark.
Int J Addict. 1990 Jan;25(1):53-63. doi: 10.3109/10826089009056200.
A cohort of 169 opiate drug addicts was followed for 8 years. The mortality rate was 3.3 per year. The average lethality per observation year was found to be higher than in other studies. The treatment with methadone was unstable and only 11% had received stable prolonged maintenance treatment. It is not possible to reject a model that described increasing mortality rates neither as a function of falling methadone maintenance treatment nor as a function of socially unstable addicts contra stable addicts. Unemployment was high in the cohort (87%), and no relationship could be demonstrated between methadone maintenance treatment and employment.
对169名阿片类药物成瘾者进行了为期8年的跟踪研究。死亡率为每年3.3%。发现每个观察年的平均致死率高于其他研究。美沙酮治疗不稳定,只有11%的人接受了稳定的长期维持治疗。无法排除这样一种模型,即死亡率上升既不是美沙酮维持治疗减少的函数,也不是社会不稳定成瘾者与稳定成瘾者对比的函数。该队列中的失业率很高(87%),未发现美沙酮维持治疗与就业之间存在关联。