连点成线：DNA双链断裂处泛素化与类泛素化修饰之间的相互作用
Connecting the Dots: Interplay between Ubiquitylation and SUMOylation at DNA Double-Strand Breaks.
作者信息
Tang Jiang-Bo, Greenberg Roger A
机构信息
Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
出版信息
Genes Cancer. 2010 Jul;1(7):787-96. doi: 10.1177/1947601910382774.
Abstract
Protein modifications, including phosphorylation, ubiquitylation, and SUMOylation, have emerged as essential components of the response to DNA double-strand breaks (DSBs). Mutations within the genes encoding effectors of these components lead to genomic instability and in selected cases, human radiosensitivity and cancer susceptibility syndromes. In this review, we highlight recent advances in the study of DSB-associated signaling events by ubiquitylation and SUMOylation and discuss how coordination among protein modification systems integrates components of the DNA damage response into a network that regulates DNA repair and transcriptional processes on contiguous stretches of chromatin.
摘要
蛋白质修饰，包括磷酸化、泛素化和类泛素化修饰，已成为对DNA双链断裂（DSB）作出反应的重要组成部分。编码这些修饰效应蛋白的基因突变会导致基因组不稳定，在某些特定情况下，还会引发人类辐射敏感性和癌症易感性综合征。在本综述中，我们重点介绍了泛素化和类泛素化修饰在DSB相关信号事件研究中的最新进展，并讨论了蛋白质修饰系统之间的协同作用如何将DNA损伤反应的各个组成部分整合到一个网络中，该网络可调控相邻染色质片段上的DNA修复和转录过程。
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本文引用的文献
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