Ohio Center for Sexual Medicine, New Albany, OH, USA.
J Sex Med. 2011 Feb;8(2):622-6. doi: 10.1111/j.1743-6109.2010.02082.x. Epub 2010 Nov 29.
Testosterone replacement therapy is the standard of care for androgen deficiency syndrome, and patients and physicians can choose among depot injectable, subcutaneously implanted pellet, transdermal patch, topical gel, and buccal tablet dosage forms. Topical gels have become popular and, although unintentional secondary transfer to a spouse or child is a known hazard, physicians and patients may underestimate the risk.
We report a case of precocious puberty in a 10-month-old male secondary to transfer of topical testosterone from his father, who was treated for primary hypogonadism.
Once the father's therapy was changed from a topical to a buccal dosage form, the symptoms in his son receded.
The potential for secondary exposure to testosterone-and its consequences-may be underappreciated by patients and by health care providers not involved in managing testosterone replacement therapy. The patient's lifestyle (e.g., contact with children, physical limitations, daily schedule) should be part of the discussion when selecting a method of testosterone replacement therapy.
睾酮替代疗法是治疗雄激素缺乏综合征的标准方法，患者和医生可以选择注射用长效制剂、皮下植入丸剂、透皮贴剂、外用凝胶和口腔片剂等剂型。外用凝胶已经很流行，尽管将药物意外转移给配偶或孩子是已知的危险，但医生和患者可能低估了这种风险。
我们报告了一例 10 个月大男婴因父亲（患有原发性性腺功能减退症）使用外用睾酮而发生性早熟的病例。
当父亲的治疗从外用改为口腔剂型时，他儿子的症状消退了。
对于非管理睾酮替代疗法的患者和医疗保健提供者来说，他们可能低估了继发接触睾酮及其后果的风险。在选择睾酮替代疗法时，应该讨论患者的生活方式（例如，与儿童的接触、身体限制、日常安排）。
