Department of Endocrinology, Affiliated Drum Tower Hospital, Medical College of Nanjing University, Jiangsu Province, China.
Clin Chim Acta. 2011 Feb 20;412(5-6):466-9. doi: 10.1016/j.cca.2010.11.030. Epub 2010 Nov 27.
Hyperglycemia could accelerate monocyte chemoattractant protein 1 (MCP-1) production in monocytes and vascular endothelial cells. Recently, a genetic polymorphism (-2518 A/G) located in MCP-1 gene promoter has been found that could influence the expression of MCP-1. A large cohort study of Caucasians reported that MCP-1 G-2518 gene variant was negatively correlated with the prevalence of insulin resistance and type 2 diabetes. However, it is unclear whether this polymorphism is associated with type 2 diabetes in Han Chinese.
We conducted a population-based case-control study of 416 type 2 diabetes cases and 416 controls.
Compared with the wild genotype AA, MCP-1 G-2518 gene variant could significantly decrease the prevalence of type 2 diabetes in Han Chinese (adjusted OR=0.49, 95% CI 0.32-0.77, P<0.0001). The results of stratified analyses indicated that a decreased risk of type 2 diabetes related with variant genotypes was evident in younger participants (age ≤50) (adjusted OR=0.35, 95% CI 0.20-0.61, P<0.0001), and similar results were observed in males (adjusted OR=0.37, 95% CI 0.21-0.66, P=0.001) and urban participants (adjusted OR=0.35, 95% CI 0.21-0.58, P<0.0001). In addition, a statistically significant difference was observed between MCP-1-2518 A/G polymorphism and waist to hip ratio.
Our present pilot study indicated that MCP-1 G-2518 gene variant could significantly decrease the risk of type 2 diabetes in a Chinese population.
高血糖可加速单核细胞趋化蛋白 1（MCP-1）在单核细胞和血管内皮细胞中的产生。最近，在 MCP-1 基因启动子中发现了一种遗传多态性（-2518A/G），它可以影响 MCP-1 的表达。一项针对白种人的大型队列研究报告称，MCP-1 G-2518 基因变异与胰岛素抵抗和 2 型糖尿病的患病率呈负相关。然而，这种多态性是否与汉族人 2 型糖尿病有关尚不清楚。
我们进行了一项基于人群的病例对照研究，共纳入 416 例 2 型糖尿病患者和 416 例对照者。
与野生基因型 AA 相比，MCP-1 G-2518 基因变异可显著降低汉族人 2 型糖尿病的患病率（校正比值比=0.49，95%可信区间 0.32-0.77，P<0.0001）。分层分析结果表明，在年龄≤50 岁的年轻参与者（校正比值比=0.35，95%可信区间 0.20-0.61，P<0.0001）和男性（校正比值比=0.37，95%可信区间 0.21-0.66，P=0.001）及城市参与者（校正比值比=0.35，95%可信区间 0.21-0.58，P<0.0001）中，与变异基因型相关的 2 型糖尿病发病风险降低更为显著。此外，MCP-1-2518A/G 多态性与腰臀比之间存在统计学差异。
本研究初步表明，MCP-1 G-2518 基因变异可显著降低汉族人群患 2 型糖尿病的风险。
