Division of Retrovirology, U.S. Military HIV Research Program, Walter Reed Army Institute of Research, 1600 East Gude Drive, Rockville, MD 20850, USA.
Vaccine. 2011 Jan 29;29(5):873-7. doi: 10.1016/j.vaccine.2010.11.049. Epub 2010 Nov 27.
Safe and effective adjuvants are needed for many vaccines with limited commercial appeal, such as vaccines to infrequent (orphan) diseases or to neglected and poverty-related diseases. Here we found that three nonproprietary liposome formulations containing monophosphoryl lipid A each induced 3-fold to 5-fold increased titers of binding and neutralizing antibodies to anthrax protective antigen compared to aluminum hydroxide-adsorbed antigen in monkeys. All vaccinated monkeys were protected against lethal challenge with aerosolized Ames strain spores.
安全有效的佐剂对于许多商业吸引力有限的疫苗是必需的，例如针对罕见（孤儿）疾病或被忽视和贫困相关疾病的疫苗。在这里，我们发现三种非专利脂质体制剂，每种制剂均含有单磷酰脂质 A，与吸附于氢氧化铝的抗原相比，能使猴体内炭疽保护性抗原的结合抗体和中和抗体滴度分别提高 3 倍至 5 倍。所有接种疫苗的猴子均能抵御雾化安姆斯株孢子的致死性攻击。
