van der Borght Karin, Köhnke Rickard, Göransson Nathanael, Deierborg Tomas, Brundin Patrik, Erlanson-Albertsson Charlotte, Lindqvist Andreas
Neuronal Survival Unit, Department of Experimental Medical Science, BMC A10, Lund University, Lund, Sweden.
Regul Pept. 2011 Feb 25;167(1):26-30. doi: 10.1016/j.regpep.2010.11.002. Epub 2010 Nov 27.
In this study, we investigated how prolonged consumption of sugar solution affects hippocampal neurogenesis. We gave rats sucrose or fructose solution for four weeks and observed a 40% reduction in BrdU/NeuN-immunoreactive cells in the hippocampal dentate gyrus. This reduction in hippocampal neurogenesis was accompanied by increased apoptosis in the hippocampus and increased circulating levels of TNF-α. Therefore, we hypothesize that the reduction in hippocampal neurogenesis may be due to the increased apoptosis induced by TNF-α. Our results suggest that chronic ingestion of fructose is detrimental to the survival of newborn hippocampal neurones. The results presented in the present study add to the list of harmful effects associated with prolonged and excessive consumption of sugary beverages and soft drinks.
在本研究中，我们调查了长期饮用糖溶液如何影响海马神经发生。我们给大鼠喂食蔗糖或果糖溶液四周，观察到海马齿状回中BrdU/NeuN免疫反应性细胞减少了40%。海马神经发生的这种减少伴随着海马中细胞凋亡增加以及循环中TNF-α水平升高。因此，我们推测海马神经发生的减少可能是由于TNF-α诱导的细胞凋亡增加所致。我们的结果表明，长期摄入果糖对新生海马神经元的存活有害。本研究中呈现的结果增加了与长期过量饮用含糖饮料和软饮料相关的有害影响的清单。
