Institute of Pathology, University of Cologne, Kerpener Str 62, 50924 Cologne, Germany.
Anticancer Res. 2010 Nov;30(11):4635-41.
Previous studies on the immunoreactivity of β-catenin, MUC1 and c-met in gastric carcinomas regarding survival and clinico-pathological features led to contradictory results. Therefore, a series of 94 diffuse-type and mixed-type subcardial gastric carcinomas according to the Laurén classification were investigated to elucidate possible correlations with clinico-pathological and prognostic data. An immunohistochemical study was performed to detect the expression of β-catenin, MUC1 and c-met. Loss of membranous/cytoplasmic β-catenin expression in the tumour centre correlated with pT, loss at the invasion front with pTNM stage. MUC1 expression in the tumour centre correlated with lymph node metastasis and pTNM stage. c-Met did not show such associations. In multivariate survival analysis, loss of membranous/ cytoplasmic β-catenin expression as well as a strong MUC1 expression at the tumour invasion front represent independent predictors of a worse prognosis. On the other hand, c-met expression did not exhibit any prognostic value in this study.
先前关于β-连环蛋白、MUC1 和 c-met 在胃癌中的免疫反应性与生存和临床病理特征的研究结果相互矛盾。因此，本研究对 94 例Laurén 分类的弥漫型和混合型贲门胃癌进行了一系列研究，以阐明其与临床病理和预后数据的可能相关性。采用免疫组织化学方法检测β-连环蛋白、MUC1 和 c-met 的表达。肿瘤中心的膜/细胞质β-连环蛋白表达缺失与 pT 相关，侵袭前缘的缺失与 pTNM 分期相关。肿瘤中心的 MUC1 表达与淋巴结转移和 pTNM 分期相关。c-Met 没有显示出这种相关性。在多变量生存分析中，膜/细胞质β-连环蛋白表达缺失以及肿瘤侵袭前缘的强 MUC1 表达是预后不良的独立预测因子。另一方面，在这项研究中，c-met 表达没有显示出任何预后价值。
