Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada.
Dev Dyn. 2011 Jan;240(1):221-31. doi: 10.1002/dvdy.22506.
The Src homology and collagen (Shc) proteins function as molecular adaptors in signaling pathways mediated by a variety of cell surface receptors. Of the four mammalian Shc proteins, ShcD is the least characterized. To this end, ShcD expression was documented and compared to that of other Shc family proteins. In the developing mouse embryo, expression of ShcD overlaps with that of other Shc proteins in the central nervous system, with specific distribution in post-mitotic neurons. In addition, robust ShcD expression is seen within differentiated epithelial cells of several organs, as well as in skeletal and cardiac muscle, and various tissues of neural crest origin. Interestingly, all Shc family members are expressed in hypertrophic chondrocytes, the first report of Shc protein expression in the developing skeleton. The unique tissue distribution patterns of Shc proteins likely contribute to their complex tissue-specific signaling functions during embryogenesis.
Src 同源和胶原 (Shc) 蛋白作为分子接头在各种细胞表面受体介导的信号通路中发挥作用。在四种哺乳动物 Shc 蛋白中，ShcD 的特征性最低。为此，记录了 ShcD 的表达并与其他 Shc 家族蛋白进行了比较。在发育中的小鼠胚胎中，ShcD 的表达与中枢神经系统中其他 Shc 蛋白重叠，在有丝分裂后神经元中有特定分布。此外，在几个器官的分化上皮细胞以及骨骼和心肌以及神经嵴来源的各种组织中也观察到强烈的 ShcD 表达。有趣的是，所有 Shc 家族成员都在肥大软骨细胞中表达，这是 Shc 蛋白在发育中的骨骼中表达的首次报道。Shc 蛋白的独特组织分布模式可能有助于它们在胚胎发生过程中发挥复杂的组织特异性信号功能。
