使用自适应光学和频域光学相干断层扫描评估玻璃膜疣上方的光感受器镶嵌。
Assessing the photoreceptor mosaic over drusen using adaptive optics and SD-OCT.
作者信息
Godara Pooja, Siebe Cory, Rha Jungtae, Michaelides Michel, Carroll Joseph
机构信息
Department of Ophthalmology, The Eye Institute, Medical College of Wisconsin, 925 North 87th Street, Milwaukee, WI 53226, USA.
出版信息
Ophthalmic Surg Lasers Imaging. 2010 Nov-Dec;41 Suppl(Suppl):S104-8. doi: 10.3928/15428877-20101031-07.
Abstract
Drusen are extracellular deposits that accumulate between the retinal pigment epithelium and Bruch's membrane. They are one of the earliest clinical manifestations of age-related macular degeneration and it is thought that they disrupt the overlying photoreceptors, leading to subsequent vision loss. The purpose of this study was to illustrate how spectral domain optical coherence tomography and adaptive optics fundus imaging can be used to quantitatively analyze the integrity of the overlying photoreceptors in a single subject with macular drusen. This imaging approach and the image analysis metrics introduced may serve as the foundation for valuable imaging-based biomarkers for detecting the earliest stages of disease, tracking progression, and monitoring treatment response.
摘要
玻璃膜疣是在视网膜色素上皮和布鲁赫膜之间积聚的细胞外沉积物。它们是年龄相关性黄斑变性最早的临床表现之一，据认为它们会破坏上方的光感受器，导致随后的视力丧失。本研究的目的是说明如何使用光谱域光学相干断层扫描和自适应光学眼底成像来定量分析一名患有黄斑玻璃膜疣的受试者上方光感受器的完整性。所介绍的这种成像方法和图像分析指标可为检测疾病最早阶段、跟踪病情进展和监测治疗反应的有价值的基于成像的生物标志物奠定基础。
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本文引用的文献
1
High resolution multimodal clinical ophthalmic imaging system.
Opt Express. 2010 May 24;18(11):11607-21. doi: 10.1364/OE.18.011607.
2
Arrested development: high-resolution imaging of foveal morphology in albinism.
Vision Res. 2010 Apr 7;50(8):810-7. doi: 10.1016/j.visres.2010.02.003. Epub 2010 Feb 10.
3
Variable optical activation of human cone photoreceptors visualized using a short coherence light source.
Opt Lett. 2009 Dec 15;34(24):3782-4. doi: 10.1364/OL.34.003782.
4
Adaptive optics optical coherence tomography at 120,000 depth scans/s for non-invasive cellular phenotyping of the living human retina.
Opt Express. 2009 Oct 26;17(22):19382-400. doi: 10.1364/OE.17.019382.
5
Cone photoreceptor mosaic disruption associated with Cys203Arg mutation in the M-cone opsin.
Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20948-53. doi: 10.1073/pnas.0910128106. Epub 2009 Nov 23.
6
Retinal imaging using commercial broadband optical coherence tomography.
Br J Ophthalmol. 2010 Mar;94(3):372-6. doi: 10.1136/bjo.2009.163501. Epub 2009 Sep 21.
7
Resolving single cone inputs to visual receptive fields.
Nat Neurosci. 2009 Aug;12(8):967-9. doi: 10.1038/nn.2352. Epub 2009 Jun 28.
8
Three-dimensional ultrahigh resolution optical coherence tomography imaging of age-related macular degeneration.
Opt Express. 2009 Mar 2;17(5):4046-60. doi: 10.1364/oe.17.004046.
9
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10
High-speed volumetric imaging of cone photoreceptors with adaptive optics spectral-domain optical coherence tomography.
Opt Express. 2006 May 15;14(10):4380-94. doi: 10.1364/OE.14.004380.
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