Simon D A, Taylor T-L, Bayley G, Lalonde K-A
Division of Orthopaedic Surgery, University of Ottawa, Faculty of Medicine, The Ottawa Hospital, General Campus, 501 Smyth Road, Ottawa, Canada, K1H 8L6.
J Bone Joint Surg Br. 2010 Dec;92(12):1700-2. doi: 10.1302/0301-620X.92B12.25225.
Systemic capillary leak syndrome, or the Clarkson syndrome, is an extremely rare condition in which increased capillary permeability results in a massive shift of fluid into the extravascular space. This is followed rapidly by hypotensive shock, haemoconcentration, and, potentially, substantial oedema of the limbs resulting in an acute compartment syndrome. It is important for orthopaedic surgeons to be aware of this syndrome as our medical colleagues, who initially care for these patients, are less familiar with the diagnosis and the need for emergency management of the associated compartment syndrome should it develop. There have been fewer than 100 cases of this entity reported. This case report is the first to describe the subsequent development of a compartment syndrome in all four limbs. Clinical vigilance and continuous monitoring of intracompartmental pressure is necessary in these patients in order to help reduce limb-threatening complications.
系统性毛细血管渗漏综合征，又称克拉克森综合征，是一种极为罕见的病症，其特征为毛细血管通透性增加，导致大量液体转移至血管外间隙。随之迅速出现低血压休克、血液浓缩，以及可能导致急性骨筋膜室综合征的四肢严重水肿。骨科医生了解这种综合征很重要，因为最初诊治这些患者的内科同事对其诊断以及相关骨筋膜室综合征一旦发生时进行紧急处理的必要性不太熟悉。报道的该病症病例不足100例。本病例报告首次描述了四肢均发生骨筋膜室综合征的后续情况。为帮助减少危及肢体的并发症，对这些患者进行临床警惕性观察并持续监测骨筋膜室内压力是必要的。
