The Robert F. Furchgott Center of Neural and Behavioural Science, Department of Physiology, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, New York 11203, USA.
Nat Rev Neurosci. 2011 Jan;12(1):9-15. doi: 10.1038/nrn2949. Epub 2010 Dec 1.
Most of the molecular mechanisms contributing to long-term memory have been found to consolidate information within a brief time window after learning, but not to maintain information during memory storage. However, with the discovery that synaptic long-term potentiation is maintained by the persistently active protein kinase, protein kinase Mζ (PKMζ), a possible mechanism of memory storage has been identified. Recent research shows how PKMζ might perpetuate information both at synapses and during long-term memory.
大多数有助于长期记忆的分子机制在学习后短暂的时间窗口内被发现可以整合信息,但不能在记忆存储过程中维持信息。然而,随着发现突触长时程增强是由持续活跃的蛋白激酶 Mζ(protein kinase Mζ,PKMζ)维持的,一种可能的记忆存储机制已经被确定。最近的研究表明 PKMζ 如何在突触和长期记忆中持续传递信息。