Suppr超能文献

PKMζ 如何维持长期记忆?

How does PKMζ maintain long-term memory?

机构信息

The Robert F. Furchgott Center of Neural and Behavioural Science, Department of Physiology, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, New York 11203, USA.

出版信息

Nat Rev Neurosci. 2011 Jan;12(1):9-15. doi: 10.1038/nrn2949. Epub 2010 Dec 1.

Abstract

Most of the molecular mechanisms contributing to long-term memory have been found to consolidate information within a brief time window after learning, but not to maintain information during memory storage. However, with the discovery that synaptic long-term potentiation is maintained by the persistently active protein kinase, protein kinase Mζ (PKMζ), a possible mechanism of memory storage has been identified. Recent research shows how PKMζ might perpetuate information both at synapses and during long-term memory.

摘要

大多数有助于长期记忆的分子机制在学习后短暂的时间窗口内被发现可以整合信息,但不能在记忆存储过程中维持信息。然而,随着发现突触长时程增强是由持续活跃的蛋白激酶 Mζ(protein kinase Mζ,PKMζ)维持的,一种可能的记忆存储机制已经被确定。最近的研究表明 PKMζ 如何在突触和长期记忆中持续传递信息。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验