婴儿期雾化吸入色甘酸钠：病情恶化后的气道保护
Nebulised sodium cromoglycate in infancy: airway protection after deterioration.
作者信息
O'Callaghan C, Milner A D, Swarbrick A
机构信息
Department of Child Health, University Hospital, Queen's Medical Centre, Nottingham.
出版信息
Arch Dis Child. 1990 Apr;65(4):404-6. doi: 10.1136/adc.65.4.404.
Over a two year period 100 infants with histories of wheeze were challenged with nebulised water. They were sedated and lung function measured by total body plethysmography. Thirteen of the 53 infants who developed bronchoconstriction after challenge with nebulised water were given nebulised sodium cromoglycate and rechallenged with nebulised water. All infants were initially challenged with normal saline, after which there was no significant change in lung function. After challenge with nebulised water and sodium cromoglycate there were significant decreases in specific conductance compared with those found after challenge with normal saline. After rechallenge with nebulised water there was no deterioration in lung function. Although sodium cromoglycate caused a deterioration in lung function in these infants, it protected their airways from challenge with nebulised water.
在两年时间里，对100名有喘息病史的婴儿进行了雾化水激发试验。他们接受了镇静，并通过全身体积描记法测量肺功能。在雾化水激发试验后出现支气管收缩的53名婴儿中，有13名接受了雾化色甘酸钠治疗，然后再次进行雾化水激发试验。所有婴儿最初均接受生理盐水激发试验，之后肺功能无明显变化。与生理盐水激发试验后相比，雾化水和色甘酸钠激发试验后比导率显著降低。再次进行雾化水激发试验后，肺功能没有恶化。尽管色甘酸钠在这些婴儿中导致了肺功能恶化，但它保护了他们的气道免受雾化水的激发。
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