Lenney W, Milner A D
Arch Dis Child. 1978 Jun;53(6):474-6. doi: 10.1136/adc.53.6.474.
A double-blind controlled study of 14 preschool children with recurrent wheezing episodes was performed to show the effectiveness of nebulised sodium cromoglycate in inhibiting exercise-induced bronchoconstriction in this age group. All 14 children showed markedly less exercise-induced bronchoconstruction after nebulised sodium cromoglycate, 13 of them to a degree indistinguishable from results obtained in normal healthy children in the same age group. Nebulised water afforded protection from exercise-induced bronchoconstriction in some children. This study gives further evidence that sodium cromoglycate is an effective therapeutic agent in children under the age of 5 years.
对14名有反复喘息发作的学龄前儿童进行了一项双盲对照研究,以证明雾化吸入色甘酸钠在抑制该年龄组运动诱发支气管收缩方面的有效性。所有14名儿童在雾化吸入色甘酸钠后运动诱发的支气管收缩明显减轻,其中13名儿童减轻的程度与同年龄组正常健康儿童的结果难以区分。雾化吸入水对一些儿童的运动诱发支气管收缩也有保护作用。这项研究进一步证明色甘酸钠是5岁以下儿童的一种有效治疗药物。