Department of Pathology, Chinese PLA General Hospital, Beijing, China.
J Zhejiang Univ Sci B. 2010 Dec;11(12):918-22. doi: 10.1631/jzus.B1000164.
Atypical lipomatous tumor (ALT) of the laryngopharynx is rare. Here we report five cases to demonstrate their clinicopathological features. The patients were four males and one female, aged 41 to 69 years (median 53.6 years). All tumors (two in the hypopharynx and three in the larynx) presented as a slowly growing, painless mass. Symptoms included dysphagia (2/5), dysphonia (3/5), and the feeling of a foreign body in the throat (5/5). Tumors were well circumscribed or focally infiltrative, ranging from 2.0 to 5.0 cm (median, 3.4 cm) in size, and microscopically showed the typical features of lipoma-like ALT. Immunohistochemically, tumor cells were stained with S-100, vimentin, murine double minute 2 (MDM-2), and cyclin-dependent kinase 4 (CDK4). Two patients had local tumor recurrences at 6 and 14 months after initial surgery during follow-up. ALT of laryngopharynx is an indolent tumor. Immunohistochemical staining for MDM-2 and CDK4 is helpful in pathological diagnosis.
喉咽非典型性脂肪肉瘤罕见。我们在此报告五例以展示其临床病理特征。患者为 4 男 1 女，年龄 41 至 69 岁（中位年龄 53.6 岁）。所有肿瘤（2 例位于下咽，3 例位于喉部）均表现为缓慢生长、无痛性肿块。症状包括吞咽困难（2/5）、发音困难（3/5）和喉部异物感（5/5）。肿瘤边界清楚或局灶性浸润，大小为 2.0 至 5.0cm（中位大小 3.4cm），镜下显示典型的脂肪肉瘤样 ALT 特征。免疫组化染色显示肿瘤细胞表达 S-100、波形蛋白、鼠双微体 2（MDM-2）和细胞周期蛋白依赖性激酶 4（CDK4）。2 例患者在初始手术后 6 个月和 14 个月的随访中出现局部肿瘤复发。喉咽非典型性脂肪肉瘤是一种惰性肿瘤。MDM-2 和 CDK4 的免疫组化染色有助于病理诊断。
