Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia.
PLoS One. 2010 Nov 19;5(11):e14066. doi: 10.1371/journal.pone.0014066.
BCG vaccine drives a strong T helper 1 cellular immunity which is essential for the protection against mycobacteria, however recent studies suggest that BCG vaccination can have non-specific beneficial effects unrelated to tuberculosis. In the present cohort study the development of cytokine profiles following BCG vaccination was investigated. Immune responses to PPD were assessed before vaccination and at ages of 5 months, 1 year, and 2 years, followed by BCG scar measurement at 4 years of age. BCG was shown to induce both Th1 and Th2 type responses against PPD at about 5 months of age after vaccination, and while Th1 response was sustained, Th2 responses declined over time. However, BCG scar size was strongly correlated with Th2 responses to PPD at 5 months of age. Importantly, we observed no clear effects of BCG vaccination on innate immune responses in terms of early IL-10 or TNF-α production whereas some alterations in general adaptive immune responses to PHA were observed.
BCG 疫苗可诱导强烈的辅助性 T 细胞 1 型细胞免疫，这对于预防分枝杆菌感染至关重要，然而最近的研究表明，BCG 接种可能具有与结核病无关的非特异性有益作用。在本队列研究中，研究了 BCG 接种后细胞因子谱的发展。在接种疫苗之前以及在 5 个月、1 岁和 2 岁时评估了对 PPD 的免疫反应，随后在 4 岁时测量了 BCG 疤痕。结果表明，BCG 接种后约 5 个月可诱导针对 PPD 的 Th1 和 Th2 型反应，虽然 Th1 反应持续存在，但 Th2 反应随时间逐渐下降。然而，BCG 疤痕大小与 5 个月时对 PPD 的 Th2 反应强烈相关。重要的是，我们没有观察到 BCG 接种对 IL-10 或 TNF-α产生等先天免疫反应的明显影响，而对 PHA 的一般适应性免疫反应则观察到一些改变。
