Malaspina Lara, Calomino Natale, Carbone Ludovico, Batsikosta Anastasia, Rossi Fabiola, Poto Gianmario Edoardo, Visani Aurora, Mundo Lucia, Barbato Bina, Monteleone Ilaria, Roviello Franco, Tripodi Sergio Antonio
Pathology Unit, Ospedale Civico di Carrara, 54033 Carrara, Italy.
Unit of General Surgery and Kidney Transplantation, Department of Surgery, Siena University Hospital, 53100 Siena, Italy.
Curr Oncol. 2025 Jun 13;32(6):352. doi: 10.3390/curroncol32060352.
Cystic mucinous neoplasms (MCNs) of the pancreas are rare cystic tumors, accounting for approximately 2-5% of all pancreatic neoplasms. They predominantly occur in premenopausal women and are typically located in the body or tail of the pancreas. Due to their potential for malignant transformation, especially in cases associated with invasive carcinoma such as pancreatic ductal adenocarcinoma, early detection, complete surgical resection, and rigorous postoperative surveillance are essential. The occurrence of MCNs in male patients is exceedingly rare, comprising only about 2% of reported cases, and often resulting in preoperative diagnostic challenges. Molecular analyses have identified a strong association between KRAS mutations and disease progression in MCNs, underscoring their potential role as prognostic markers despite limited diagnostic utility. In this report, we present two additional cases of MCNs in male patients, highlighting their histopathological features and the ancillary investigations undertaken to support diagnosis.
胰腺黏液性囊性肿瘤（MCNs）是罕见的囊性肿瘤，约占所有胰腺肿瘤的2%-5%。它们主要发生在绝经前女性中，通常位于胰腺体部或尾部。由于其有恶变的可能，特别是在与浸润性癌如胰腺导管腺癌相关的病例中，早期发现、完整的手术切除以及严格的术后监测至关重要。男性患者中MCNs的发生极为罕见，仅占报告病例的约2%，且常常导致术前诊断困难。分子分析已确定KRAS突变与MCNs疾病进展之间存在密切关联，这突出了它们作为预后标志物的潜在作用，尽管其诊断效用有限。在本报告中，我们又介绍了两例男性患者的MCNs病例，突出了它们的组织病理学特征以及为支持诊断而进行的辅助检查。
