McLean Hospital, 115 Mill Street, Belmont, MA 02478, United States.
J Psychiatr Res. 2011 Jun;45(6):823-8. doi: 10.1016/j.jpsychires.2010.10.015. Epub 2010 Dec 3.
Self-mutilation is a common and serious problem in patients with borderline personality disorder (BPD). The purpose of this study was to determine the most clinically relevant baseline and time-varying predictors of self-mutilation over 10 years of prospective follow-up among patients with BPD.
Four semistructured interviews assessing axis I disorders, childhood adversity, adult experiences of abuse, and experiences of self-mutilation were administered at baseline to 290 patients meeting DIB-R and DSM-III-R criteria for BPD. Three of these interviews (all except for the childhood adversity interview) and two self-report measures pertaining to dysphoric affects and cognitions were administered at each of five contiguous two-year follow-up periods.
Eleven variables were found to be significant bivariate predictors of self-mutilation over the five follow-up periods. Six of these predictors remained significant in multivariate analyses: female gender, severity of dysphoric cognitions (mostly overvalued ideas), severity of dissociative symptoms, major depression, history of childhood sexual abuse, and sexual assaults as an adult.
Taken together, the results of this study suggest that factors pertaining to traumatic experiences throughout the lifespan are significant risk factors for self-mutilation over time. These results also suggest that major depressive episodes and cognitive symptoms, particularly overvalued ideas and dissociation, significantly heighten the risk of self-injurious behaviors tracked for a decade.
边缘型人格障碍(BPD)患者中,自残行为是一种常见且严重的问题。本研究旨在确定在 BPD 患者 10 年的前瞻性随访中,最具临床相关性的基线和时变预测因素。
在基线时,对符合 DIB-R 和 DSM-III-R 标准的 290 名 BPD 患者进行了 4 次半结构化访谈,评估了轴 I 障碍、童年逆境、成年期虐待经历和自残经历。其中 3 次访谈(除了童年逆境访谈)和 2 次关于抑郁情绪和认知的自我报告测量,在 5 个连续的两年随访期内进行。
发现 11 个变量与 5 个随访期的自残行为存在显著的双变量相关性。在多变量分析中,其中 6 个预测因素仍然显著:女性性别、抑郁认知的严重程度(主要是过高的观念)、解离症状的严重程度、重度抑郁症、童年性虐待史和成年期的性侵犯。
综上所述,本研究的结果表明,与整个生命周期中的创伤经历相关的因素是自残行为随时间变化的重要危险因素。这些结果还表明,重度抑郁发作和认知症状,特别是过高的观念和解离,显著增加了追踪 10 年的自伤行为的风险。