Department of Epidemiology, Boston University School of Public Health, Boston, MA 02118, USA.
Reprod Toxicol. 2011 Feb;31(2):151-7. doi: 10.1016/j.reprotox.2010.11.006. Epub 2010 Dec 2.
Diethylstilbestrol (DES), a synthetic estrogen used in pregnancy during the 1950s and 1960s, provides a model for potential health effects of endocrine disrupting compounds in the environment. We evaluated prenatal exposure to DES, based on medical record review, in relation to gestational length, fetal growth, and age at menarche in 4429 exposed and 1427 unexposed daughters. DES exposure was associated with an increase in preterm birth (odds ratio (OR)=2.97; 95% CI=2.27, 3.87), and a higher risk of small for gestational age (SGA) (OR=1.61; 95% CI=1.31, 1.98). The association between DES exposure and early menarche was borderline, with stronger effects when early menarche was defined as ≤ 10 years (OR=1.41 95% CI=0.97, 2.03) than defined as ≤ 11 years (OR=1.16; 95% CI=0.97, 1.39). This study provides evidence that prenatal DES exposure was associated with fetal growth and gestational length, which may mediate associations between DES and health outcomes in later life.
己烯雌酚（DES）是一种在 20 世纪 50 年代和 60 年代用于妊娠的合成雌激素，为环境内分泌干扰物对健康的潜在影响提供了一个模型。我们评估了基于医疗记录回顾的产前暴露于 DES 与妊娠持续时间、胎儿生长和初潮年龄之间的关系，共涉及 4429 名暴露组和 1427 名未暴露组的女儿。DES 暴露与早产风险增加相关（比值比（OR）=2.97；95%置信区间（CI）=2.27, 3.87），以及胎儿生长受限（SGA）的风险增加（OR=1.61；95% CI=1.31, 1.98）。DES 暴露与初潮提前之间的关联具有边缘显著性，当将初潮提前定义为≤10 岁时（OR=1.41 95% CI=0.97, 2.03），其关联比定义为≤11 岁（OR=1.16；95% CI=0.97, 1.39）时更强。这项研究提供了证据表明产前 DES 暴露与胎儿生长和妊娠持续时间有关，这可能介导了 DES 与以后生命中健康结果之间的关联。
