Kofoed H, Lindenberg S
Injury. 1986 Jul;17(4):274-6. doi: 10.1016/0020-1383(86)90236-6.
The purpose of the present study was to investigate the effect of simulated joint effusion on pO2, pCO2, the regional blood flow and intraosseous bone marrow pressure in the subchondral bone of rabbit. Mass spectrometry was used for simultaneous and continuous registration of subchondral pO2 and pCO2, while the relative argon signal was used for qualitative estimation of regional bone blood flow. The bone marrow pressure was recorded continuously by pressure transducers. Isotonic sodium chloride infusion at a constant pressure of 75 mmHg into the knee joint cavity constituted the basis for joint effusion. An instant increase in the subchondral bone marrow pressure followed the joint effusion (P less than 0.001). This resulted in a significant (P less than 0.01) decrease in the qualitative bone blood flow, significant (P less than 0.01) hypoxia and significant (P less than 0.01) hypercapnia in the subchondral bone. Joint effusion always lasted 30 minutes. Following its release all changes were reversed to normal values within 15 minutes. Within the period of observation no nervous or humoral factors seem to be brought into action. It was concluded that regional venous stasis was responsible for all changes, and that joint effusion should not be left untreated for long periods.
本研究的目的是探讨模拟关节积液对兔软骨下骨的pO2、pCO2、局部血流及骨髓腔内压力的影响。采用质谱法同时连续记录软骨下pO2和pCO2，而相对氩信号用于定性评估局部骨血流。通过压力传感器连续记录骨髓压力。以75 mmHg的恒定压力向膝关节腔内输注等渗氯化钠溶液作为关节积液的基础。关节积液后软骨下骨髓压力立即升高（P<0.001）。这导致软骨下骨的定性骨血流显著降低（P<0.01）、显著缺氧（P<0.01）和显著高碳酸血症（P<0.01）。关节积液持续30分钟。积液释放后，所有变化在15分钟内恢复到正常值。在观察期内，似乎没有神经或体液因素起作用。得出的结论是，局部静脉淤滞是所有变化的原因，关节积液不应长期不治疗。
