Kiaer T, Dahl B, Lausten G
Department of Orthopaedic Surgery U, Rigshospitalet, Copenhagen, Denmark.
J Orthop Res. 1992 Nov;10(6):807-12. doi: 10.1002/jor.1100100609.
Pathological changes in bone have been related to a preceding impediment of the arterial or venous bone circulation and hypoxia. In this study, we analyzed the feasibility of mass spectrometry in measuring intraosseous oxygen and carbon dioxide. The partial pressures were also measured in intraosseous blood samples, and blood flow in bone was measured with the radioactive microspheres technique. The average partial pressure of oxygen in the lateral femoral condyle was 34 +/- 1.6 mm Hg when measured in intraosseous blood samples and 36.3 +/- 2.3 mm Hg when measured with the on-line mass spectrometer, with significant correlation between the methods. The absolute value of the partial pressure of carbon dioxide measured in situ with mass spectrometry was correlated with the value in the withdrawn blood. There was no significant difference in partial pressures of oxygen and carbon dioxide between the two sides or between repetitive measurements. Arterial occlusion resulted in severe hypoxia, whereas more moderate changes followed venous occlusion.
骨骼的病理变化与先前动脉或静脉骨循环障碍及缺氧有关。在本研究中，我们分析了质谱法测量骨内氧气和二氧化碳的可行性。还测量了骨内血样中的分压，并采用放射性微球技术测量了骨内血流。在骨内血样中测量时，股骨外侧髁的平均氧分压为34±1.6毫米汞柱，使用在线质谱仪测量时为36.3±2.3毫米汞柱，两种方法之间存在显著相关性。用质谱法原位测量的二氧化碳分压绝对值与采出的血液中的值相关。两侧之间或重复测量之间的氧气和二氧化碳分压无显著差异。动脉闭塞导致严重缺氧，而静脉闭塞后变化更为中度。
