Reid David, Morton Randall, Salkeld Lesley, Bartley Jim
Division of Otolaryngology-Head and Neck Surgery, Counties-Manukau District Health Board, Auckland, New Zealand.
Int J Pediatr Otorhinolaryngol. 2011 Feb;75(2):261-4. doi: 10.1016/j.ijporl.2010.11.012. Epub 2010 Dec 4.
To estimate the prevalence of 25(OH) vitamin D deficiency in children undergoing (adeno)tonsillectomy.
From 1st November 2008 to 20th December 2008, 33 children aged from 4 to 16 and resident in Auckland, New Zealand (latitude 36° 52' S) undergoing (adeno)tonsillectomy for difficulty breathing/sleep apnoea and/or recurrent tonsillitis had 25(OH) vitamin D, iron and zinc levels measured.
Of the 32 patients who had 25(OH) vitamin D levels measured, 15.6% were vitamin D deficient (25(OH) vitamin D<50nmol/L), and 78% had levels, <75nmol/L. 25(OH) vitamin D level was inversely correlated with Fitzpatrick skin type (Spearman's rho=-0.713, p<0.01), body mass index (BMI) (Spearman's rho=-0.434, p=0.013) and tonsil size (Spearman's rho=-0.417, p=0.017). However regression modeling demonstrated that only Fitzpatrick skin type (β=-0.687, p=0.001) and BMI (β=-0.256, p=0.044) were significant predictors of vitamin D levels (R(2)=0.572).
Seventy-eight percent of Auckland children undergoing (adeno)tonsillectomy had a 25(OH) vitamin D level<75nmol/L, a level which is associated with an increased incidence of upper respiratory tract infection. Low 25(OH) vitamin D levels were related to a darker skin, increased BMI and larger assessed tonsil size. The association of larger tonsil size with lower 25(OH) vitamin D status needs further evaluation but offers a potential explanation why black and Hispanic children are more likely than white children to have (adeno)tonsillectomy for snoring or obstructive sleep apnoea.
评估接受（腺）扁桃体切除术的儿童中25（OH）维生素D缺乏症的患病率。
2008年11月1日至2008年12月20日，对33名年龄在4至16岁、居住在新西兰奥克兰（南纬36°52'）、因呼吸困难/睡眠呼吸暂停和/或复发性扁桃体炎而接受（腺）扁桃体切除术的儿童进行了25（OH）维生素D、铁和锌水平的检测。
在32名检测了25（OH）维生素D水平的患者中，15.6%维生素D缺乏（25（OH）维生素D<50nmol/L），78%的患者水平<75nmol/L。25（OH）维生素D水平与菲茨帕特里克皮肤类型（斯皮尔曼等级相关系数=-0.713，p<0.01）、体重指数（BMI）（斯皮尔曼等级相关系数=-0.434，p=0.013）和扁桃体大小（斯皮尔曼等级相关系数=-0.417，p=0.017）呈负相关。然而，回归模型显示，只有菲茨帕特里克皮肤类型（β=-0.687，p=0.001）和BMI（β=-0.256，p=0.044）是维生素D水平的显著预测因素（R²=0.572）。
78%接受（腺）扁桃体切除术的奥克兰儿童25（OH）维生素D水平<75nmol/L，这一水平与上呼吸道感染发病率增加有关。低25（OH）维生素D水平与肤色较深、BMI增加和评估的扁桃体较大有关。扁桃体较大与较低的25（OH）维生素D状态之间的关联需要进一步评估，但这可能解释了为什么黑人和西班牙裔儿童比白人儿童更有可能因打鼾或阻塞性睡眠呼吸暂停而接受（腺）扁桃体切除术。
