Division of Plastic and Reconstructive Surgery, University of Wisconsin-Madison, School of Medicine and Public Health, Madison, Wisconsin, USA.
Aesthet Surg J. 2010 Nov-Dec;30(6):838-42. doi: 10.1177/1090820X10386364.
Based on a variety of preclinical studies showing that mesenchymal stem cells (MSC) play a significant role in tissue repair and homeostasis, MSC have rapidly moved into a phase of clinical trials investigating their efficacy as a cell-based therapeutic modality for a diverse group of applications. An emerging body of evidence shows that in addition to being a progenitor cell population with self-renewing and multipotent differentiation capabilities, MSC have unique immunomodulatory properties, making them even more attractive for regenerative medicine. Emerging discoveries in stem cell biology have revealed a multitude of mechanisms through which MSC could potentially augment the current techniques in aesthetic surgery. In this article, the authors review the clinical advances in cell-based therapies relevant to aesthetic surgery, including tissue augmentation, rejuvenation, and regeneration.
基于大量临床前研究表明间充质干细胞（MSC）在组织修复和稳态中发挥重要作用，MSC 已迅速进入临床试验阶段，研究其作为一种基于细胞的治疗方式在多种应用中的疗效。越来越多的证据表明，MSC 除了是具有自我更新和多能分化能力的祖细胞群体外，还具有独特的免疫调节特性，这使得它们在再生医学中更具吸引力。干细胞生物学的新发现揭示了 MSC 可能增强当前美容外科技巧的多种机制。在本文中，作者综述了与美容外科学相关的基于细胞的治疗的临床进展，包括组织增强、年轻化和再生。
